CP 809101 hydrochloride
Chemical Name: 2-[(3-Chlorophenyl)methoxy]-6-(1-piperazinyl)pyrazine hydrochloride
Biological ActivityPotent and selective 5-HT2C receptor agonist (pEC50 values are 9.96, 7.19 and 6.81 for human 5-HT2C, 5-HT2B and 5-HT2A receptors respectively). Displays antipsychotic activity; suppresses condition avoidance responding (CAR) and inhibits PCP and amphetamine-stimulated hyperactivity in rats following subcutaneous administration.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
CP-809,101, a selective 5-HT2C agonist, shows activity in animal models of antipsychotic activity.
Siuciak et al.
Genotoxicity of 2-(3-chlorobenzyloxy)-6-(piperazinyl)pyrazine, a novel 5-hydroxytryptamine2c receptor agonist for the treatment of obesity: role of metabolic activation.
Kalgutkar et al.
Drug Metab.Dispos., 2007;35:848
Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-d]azepin-3-ol analogues: novel 5-HT2A/5-HT2C receptor agonists with pro-cognitive
Jensen et al.
Citations for CP 809101 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for CP 809101 hydrochloride include:
5 Citations: Showing 1 - 5
Loss of GluN2D subunit results in social recognition deficit, social stress, 5-HT2C receptor dysfunction, and anhedonia in mice.
Pronociceptive and Antinociceptive Effects of Bupren. in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude.
Authors: Gerhold Et al.
J Neurosci 2015;35:9580
Serotonergic hallucinogens differentially modify gamma and high frequency oscillations in the rat nucleus accumbens.
Authors: Goda Et al.
Psychopharmacology (Berl) 2013;228:271
First and second generation antipsychotics influence hippocampal gamma oscillations by interactions with 5-HT3 and D3 receptors.
Authors: Schulz Et al.
Br J Pharmacol 2012;167:1480
5-hydroxytryptamine 2C receptors tonically augment synaptic currents in the nucleus tractus solitarii.
Authors: Austgen Et al.
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