Potent and selective 5-HT2C
receptor agonist (pEC50
values are 9.96, 7.19 and 6.81 for human 5-HT2C
receptors respectively). Displays antipsychotic activity; suppresses condition avoidance responding (CAR) and inhibits PCP and amphetamine-stimulated hyperactivity in rats following subcutaneous administration.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
CP-809,101, a selective 5-HT2C agonist, shows activity in animal models of antipsychotic activity.
Siuciak et al.
Genotoxicity of 2-(3-chlorobenzyloxy)-6-(piperazinyl)pyrazine, a novel 5-hydroxytryptamine2c receptor agonist for the treatment of obesity: role of metabolic activation.
Kalgutkar et al.
Drug Metab.Dispos., 2007;35:848
Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-d]azepin-3-ol analogues: novel 5-HT2A/5-HT2C receptor agonists with pro-cognitive
Jensen et al.
The citations listed below are publications that use Tocris products. Selected citations for CP 809101 hydrochloride include:
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