Catalog Number: 3041
Chemical Name: 2-[(3-Chlorophenyl)methoxy]-6-(1-piperazinyl)pyrazine hydrochloride
Biological Activity
Potent and selective 5-HT2C receptor agonist (pEC50 values are 9.96, 7.19 and 6.81 for human 5-HT2C, 5-HT2B and 5-HT2A receptors respectively). Displays antipsychotic activity; suppresses condition avoidance responding (CAR) and inhibits PCP and amphetamine-stimulated hyperactivity in rats following subcutaneous administration.
Technical Data
  • M.Wt:
    341.24
  • Formula:
    C15H17N4OCl.HCl
  • Solubility:
    Soluble to 20 mM in water and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at RT
  • CAS No:
    1215721-40-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. CP-809,101, a selective 5-HT2C agonist, shows activity in animal models of antipsychotic activity.
    Siuciak et al.
    Neuropharmacology, 2007;52:279
  2. Genotoxicity of 2-(3-chlorobenzyloxy)-6-(piperazinyl)pyrazine, a novel 5-hydroxytryptamine2c receptor agonist for the treatment of obesity: role of metabolic activation.
    Kalgutkar et al.
    Drug Metab.Dispos., 2007;35:848
  3. Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-d]azepin-3-ol analogues: novel 5-HT2A/5-HT2C receptor agonists with pro-cognitive
    Jensen et al.
    J.Med.Chem, 2013;56:1211
Citations:

The citations listed below are publications that use Tocris products. Selected citations for CP 809101 hydrochloride include:

5 Citations: Showing 1 - 5
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  1. Loss of GluN2D subunit results in social recognition deficit, social stress, 5-HT2C receptor dysfunction, and anhedonia in mice.
    Authors: Yamamoto
    Neuropharmacology 2017;112:188
  2. Pronociceptive and Antinociceptive Effects of Buprenorphine in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude.
    Authors: Gerhold Et al.
    J Neurosci 2015;35:9580
  3. Serotonergic hallucinogens differentially modify gamma and high frequency oscillations in the rat nucleus accumbens.
    Authors: Goda Et al.
    Psychopharmacology (Berl) 2013;228:271
  4. First and second generation antipsychotics influence hippocampal gamma oscillations by interactions with 5-HT3 and D3 receptors.
    Authors: Schulz Et al.
    Br J Pharmacol 2012;167:1480
  5. 5-hydroxytryptamine 2C receptors tonically augment synaptic currents in the nucleus tractus solitarii.
    Authors: Austgen Et al.
    Oncotarget 2012;108:2292

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