CPPHA

Key Product Details

Product Description

CPPHA is a positive allosteric modulator at mGlu₁ and mGlu₅; thought to act at a novel allosteric site. Potentiates mGlu₅ responses by a mechanism distinct from that of VU 29 (Cat. No. 4458).

Product Specifications for CPPHA

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for CPPHA

The following data is based on the product molecular weight 406.82.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.46 mL	12.29 mL	24.58 mL
5 mM	0.49 mL	2.46 mL	4.92 mL
10 mM	0.25 mL	1.23 mL	2.46 mL
50 mM	0.05 mL	0.25 mL	0.49 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Chen N-{4-Chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide (CPPHA) acts through a novel site as a positive allosteric modulator of group 1 metabotropic glutamate receptors. J.Pharmacol.Exp.Ther. 2008 PMID: 18056795
• O'Brien A novel selective allosteric modulator potentiates the activity of native metabotropic glutamate receptor subtype 5 in rat forebrain. J.Pharmacol.Exp.Ther. 2004 PMID: 14747613

Product Documents for CPPHA