Catalog Number: 4787
Chemical Name: N-[4-Chloro-2-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]phenyl]-2-hydroxybenzamide
Biological Activity
Positive allosteric modulator at mGlu1 and mGlu5; thought to act at a novel allosteric site. Potentiates mGlu5 responses by a mechanism distinct from that of VU 29 (Cat. No. 4458).
Technical Data
  • M.Wt:
    406.82
  • Formula:
    C22H15ClN2O4
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    693288-97-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. A novel selective allosteric modulator potentiates the activity of native metabotropic glutamate receptor subtype 5 in rat forebrain.
    O'Brien et al.
    J.Pharmacol.Exp.Ther., 2004;309:568
  2. N-{4-Chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide (CPPHA) acts through a novel site as a positive allosteric modulator of group 1 metabotropic glutamate receptors.
    Chen et al.
    J.Pharmacol.Exp.Ther., 2008;73:909

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