Chemical Name: 4-[3-(2-Chlorophenyl)-2-propen-1-ylidene]-1-phenyl-3,5-pyrazolidinedione
Biological ActivityDOCK2-Rac1 interaction inhibitor; suppresses DOCK2-induced Rac1 activation. Also inhibits DOCK1 and DOCK5. Exhibits selectivity over DOCK9. Reduces chemotactic responses in vitro and in vivo, and activates T cells in vitro. Also attenuates HER2-mediated breast cancer cell migration in vitro.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Blockade of inflammatory responses by a small-molecule inhibitor of the Rac activator DOCK2.
Nishikimi et al.
Rac-specific guanine nucleotide exchange factor DOCK1 is a critical regulator of HER2-mediated breast cancer metastasis.
Laurin et al.
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