Catalog Number: 4568
Chemical Name: 4-[3-(2-Chlorophenyl)-2-propen-1-ylidene]-1-phenyl-3,5-pyrazolidinedione
Biological Activity
DOCK2-Rac1 interaction inhibitor; suppresses DOCK2-induced Rac1 activation. Also inhibits DOCK1 and DOCK5. Exhibits selectivity over DOCK9. Reduces chemotactic responses in vitro and in vivo, and activates T cells in vitro. Also attenuates HER2-mediated breast cancer cell migration in vitro.
Technical Data
  • M.Wt:
    324.76
  • Formula:
    C18H13ClN2O2
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    310460-39-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Blockade of inflammatory responses by a small-molecule inhibitor of the Rac activator DOCK2.
    Nishikimi et al.
    Chem.Biol., 2012;19:488
  2. Rac-specific guanine nucleotide exchange factor DOCK1 is a critical regulator of HER2-mediated breast cancer metastasis.
    Laurin et al.
    Proc.Natl.Acad.Sci.U.S.A., 2013;110:7434

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