Chemical Name: 4-[3-(2-Chlorophenyl)-2-propen-1-ylidene]-1-phenyl-3,5-pyrazolidinedione
Biological ActivityCPYPP is a DOCK2-Rac1 interaction inhibitor; suppresses DOCK2-induced Rac1 activation. Also inhibits DOCK1 and DOCK5. Exhibits selectivity over DOCK9. Reduces chemotactic responses in vitro and in vivo, and activates T cells in vitro. Also attenuates HER2-mediated breast cancer cell migration in vitro.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Blockade of inflammatory responses by a small-molecule inhibitor of the Rac activator DOCK2.
Nishikimi et al.
Rac-specific guanine nucleotide exchange factor DOCK1 is a critical regulator of HER2-mediated breast cancer metastasis.
Laurin et al.
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