CRID3 sodium salt
Chemical Name: N-[[(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-2-furansulfonamide sodium salt
Biological ActivityCRID3 sodium salt is a potent NLRP3 inflammasome inhibitor; closes the active conformation of NLRP3 to the inactive state. Directly interacts with the Walker B motif within the NLRP3 NACHT domain. Inhibits IL-1β, IL-18 and IL-1α production (IC50 values are 7.2, 10.3 and 12-18 nM, respectively). Selective for NLRP3 over NLRC4 inflammasome and Toll-like receptor signaling. Reduces severity of experimental autoimmune encephalomyelitis, skin inflammation and airway inflammation in mice. Also glutathione S-transferase omega 1 inhibitor. Orally bioavailable.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases.
Coll et al.
Inflammasome inhibition prevents a-synuclein pathology and dopaminergic neurodegeneration in mice.
Gordon et al.
MCC950 closes the active conformation of NLRP3 to an inactive state.
Tapia-Abellán et al.
MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition.
Coll et al.
Glutathione S-transferase omega 1-1 is a target of cytokine release inhibitory drugs and may be responsible for their effect on interleukin-1β posttranslational processing.
Laliberte et al.
Citations for CRID3 sodium salt
The citations listed below are publications that use Tocris products. Selected citations for CRID3 sodium salt include:
10 Citations: Showing 1 - 10
Interleukin 38 alleviates aortic valve calcification by inhibition of NLRP3.
Authors: David A Et al.
Proc Natl Acad Sci U S A 2022;119:e2202577119
Maternal P2X7 receptor inhibition prevents autism-like phenotype in male mouse offspring through the NLRP3-IL-1β pathway.
Authors: Flóra Et al.
Brain Behav Immun 2022;101:318-332
An in vitro study of ApxI from Actinobacillus pleuropneumoniae serotype 10 and induction of NLRP3 inflammasome-dependent cell death.
Authors: Eduardo Et al.
Vet Rec Open 2021;8:e20
Inhibition of the NLRP3 inflammasome by HSP90 inhibitors.
Authors: Catherine B Et al.
CARD8 inflammasome activation triggers pyroptosis in human T cells.
Authors: Oliver T Et al.
EMBO J 2020;39:e105071
Eldecalcitol Inhibits LPS-Induced NLRP3 Inflammasome-Dependent Pyroptosis in Human Gingival Fibroblasts by Activating the Nrf2/HO-1 Signaling Pathway.
Authors: Minqi Et al.
Drug Des Devel Ther 2020;14:4901-4913
Inhibition of Amyloid-Beta Production, Associated Neuroinflammation, and Histone Deacetylase 2-Mediated Epigenetic Modifications Prevent Neuropathology in Alzheimer's Disease in vitro Model.
Authors: Nagesh Et al.
Front Aging Neurosci 2020;11:342
Genetic and pharmacological inhibition of inflammasomes reduces the survival of Mycobacterium tuberculosis strains in macrophages.
Authors: Nitya Et al.
Sci Rep 2020;10:3709
Enteropathogenic Escherichia coli Stimulates Effector-Driven Rapid Caspase-4 Activation in Human Macrophages.
Authors: Goddard Et al.
Cell Rep 2019;27:1008
BAX/BAK-Induced Apoptosis Results in Caspase-8-Dependent IL-1β Maturation in Macrophages.
Authors: Chauhan Et al.
Cell Rep 2018;25:2354
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