CRID3 sodium salt
Chemical Name: N-[[(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-2-furansulfonamide sodium salt
Biological ActivityPotent NLRP3 inflammasome inhibitor; closes the active conformation of NLRP3 to the inactive state. Directly interacts with the Walker B motif within the NLRP3 NACHT domain. Inhibits IL-1β, IL-18 and IL-1α production (IC50 values are 7.2, 10.3 and 12-18 nM, respectively). Selective for NLRP3 over NLRC4 inflammasome and Toll-like receptor signaling. Reduces severity of experimental autoimmune encephalomyelitis, skin inflammation and airway inflammation in mice. Also glutathione S-transferase omega 1 inhibitor. Orally bioavailable.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Glutathione S-transferase omega 1-1 is a target of cytokine release inhibitory drugs and may be responsible for their effect on interleukin-1β posttranslational processing.
Laliberte et al.
A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases.
Coll et al.
Inflammasome inhibition prevents a-synuclein pathology and dopaminergic neurodegeneration in mice.
Gordon et al.
MCC950 closes the active conformation of NLRP3 to an inactive state.
Tapia-Abellán et al.
MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition.
Coll et al.
Citations for CRID3 sodium salt
The citations listed below are publications that use Tocris products. Selected citations for CRID3 sodium salt include:
2 Citations: Showing 1 - 2
Enteropathogenic Escherichia coli Stimulates Effector-Driven Rapid Caspase-4 Activation in Human Macrophages.
Authors: Goddard Et al.
Cell Rep 2019;27:1008
BAX/BAK-Induced Apoptosis Results in Caspase-8-Dependent IL-1β Maturation in Macrophages.
Authors: Chauhan Et al.
Cell Rep 2018;25:2354
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