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Catalog Number:5479
Alternate Names:CP-456773, MCC 950
Chemical Name:N-[[(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-2-furansulfonamide sodium salt
Product Details
Reviews
Biological Activity
Potent NLRP3 inflammasome inhibitor; inhibits IL-1β (IC50 = 7.2 nM), IL-1α (IC50 = 12-18 nM) and IL-18 (IC50 = 10.3 nM) production. Selective for NLRP3 inflammasome over NLRC4 inflammasome and Toll-like receptor signaling. Inhibits inflammasome activation by soluble and crystalline NLRP3 stimuli. Reduces severity of experimental autoimmune encephalomyelitis, skin inflammation and airway inflammation in mice. Also glutathione S-transferase omega 1 inhibitor. Orally bioavailable.
Potent NLRP3 inflammasome inhibitor; inhibits IL-1β (IC50 = 7.2 nM), IL-1α (IC50 = 12-18 nM) and IL-18 (IC50 = 10.3 nM) production. Selective for NLRP3 inflammasome over NLRC4 inflammasome and Toll-like receptor signaling. Inhibits inflammasome activation by soluble and crystalline NLRP3 stimuli. Reduces severity of experimental autoimmune encephalomyelitis, skin inflammation and airway inflammation in mice. Also glutathione S-transferase omega 1 inhibitor. Orally bioavailable.
Technical Data
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M.Wt:426.46
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Formula:C20H23N2NaO5S
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Solubility:Soluble to 100 mM in water and to 100 mM in DMSO
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Purity:>98
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Storage:Store at +4°C
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CAS No:256373-96-3
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc
Product Datasheets
Tocris Bioscience is the leading supplier of novel and exclusive tools for
life science research with over 30 years' experience in the industry.
Tocris is a Bio-Techne brand.