Catalog Number: 5479
Alternate Names: CP-456773, MCC 950
Chemical Name: N-[[(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-2-furansulfonamide sodium salt
Biological Activity
Potent NLRP3 inflammasome inhibitor; inhibits IL-1β production (IC50 = 7.5 nm). Selective for NLRP3 inflammasome over NLRC4 inflammasome and Toll-like receptor signaling. Reduces severity of experimental autoimmune encephalomyelitis in mice. Also glutathione S-transferase omega 1 inhibitor. Orally bioavailable.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc
Background References
  1. The cytokine release inhibitory drug CRID3 targets ASC oligomerisation in the NLRP3 and AIM2 inflammasomes.
    Coll et al.
    PLoS One, 2011;6:e29539
  2. Glutathione S-transferase omega 1-1 is a target of cytokine release inhibitory drugs and may be responsible for their effect on interleukin-1β posttranslational processing.
    Laliberte et al.
    J.Biol.Chem., 2003;278:16567
  3. A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases.
    Coll et al.
    Nat.Med., 2015;21:248
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