CRID3 sodium salt

Key Product Details

Product Description

CRID3 sodium salt is a potent NLRP3 inflammasome inhibitor; closes the active conformation of NLRP3 to the inactive state. Directly interacts with the Walker B motif within the NLRP3 NACHT domain. Inhibits IL-1β, IL-18 and IL-1α production (IC₅₀ values are 7.2, 10.3 and 12-18 nM, respectively). Selective for NLRP3 over NLRC4 inflammasome and Toll-like receptor signaling. Reduces severity of experimental autoimmune encephalomyelitis, skin inflammation and airway inflammation in mice. Also glutathione S-transferase omega 1 inhibitor. Orally bioavailable.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc

Product Specifications for CRID3 sodium salt

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for CRID3 sodium salt

The following data is based on the product molecular weight 426.46.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.34 mL	11.72 mL	23.45 mL
5 mM	0.47 mL	2.34 mL	4.69 mL
10 mM	0.23 mL	1.17 mL	2.34 mL
50 mM	0.05 mL	0.23 mL	0.47 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 20 publications citing the usage of this product.

• Coll MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition. Nat.Chem.Biol. 2019 PMID: 31086327
• Tapia-Abellán MCC950 closes the active conformation of NLRP3 to an inactive state. Nat.Chem.Biol. 2019 PMID: 31086329
• Coll A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases. Nat.Med. 2015 PMID: 25686105
• Gordon Inflammasome inhibition prevents a-synuclein pathology and dopaminergic neurodegeneration in mice. Sci.Transl.Med. 2018 PMID: 30381407
• Laliberte Glutathione S-transferase omega 1-1 is a target of cytokine release inhibitory drugs and may be responsible for their effect on interleukin-1β posttranslational processing. J.Biol.Chem. 2003 PMID: 12624100

Product Documents for CRID3 sodium salt