CRID3 sodium salt
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Description: Potent NLRP3 inflammasome inhibitor; inhibits IL-1β production
Alternative Names: CP-456773, MCC 950
Chemical Name: N-[[(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-2-furansulfonamide sodium salt
Purity: ≥98%
Biological Activity
Potent NLRP3 inflammasome inhibitor; inhibits IL-1β (IC50 = 7.2 nM), IL-1α (IC50 = 12-18 nM) and IL-18 (IC50 = 10.3 nM) production. Selective for NLRP3 inflammasome over NLRC4 inflammasome and Toll-like receptor signaling. Inhibits inflammasome activation by soluble and crystalline NLRP3 stimuli. Reduces severity of experimental autoimmune encephalomyelitis, skin inflammation and airway inflammation in mice. Also glutathione S-transferase omega 1 inhibitor. Orally bioavailable.Technical Data
M.Wt:
426.46
Formula:
C20H23N2NaO5S
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
256373-96-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc
Background References
-
Glutathione S-transferase omega 1-1 is a target of cytokine release inhibitory drugs and may be responsible for their effect on interleukin-1β posttranslational processing.
Laliberte et al.
J.Biol.Chem., 2003;278:16567 -
A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases.
Coll et al.
Nat.Med., 2015;21:248
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