CRID3 sodium salt

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5479/50
Cat.No. 5479 - CRID3 sodium salt | C20H23N2NaO5S | CAS No. 256373-96-3
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Description: Potent NLRP3 inflammasome inhibitor; inhibits IL-1β production
Alternative Names: CP-456773, MCC 950

Chemical Name: N-[[(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-2-furansulfonamide sodium salt

Purity: ≥98%

Product Details
Reviews

Biological Activity

Potent NLRP3 inflammasome inhibitor; inhibits IL-1β (IC50 = 7.2 nM), IL-1α (IC50 = 12-18 nM) and IL-18 (IC50 = 10.3 nM) production. Selective for NLRP3 inflammasome over NLRC4 inflammasome and Toll-like receptor signaling. Inhibits inflammasome activation by soluble and crystalline NLRP3 stimuli. Reduces severity of experimental autoimmune encephalomyelitis, skin inflammation and airway inflammation in mice. Also glutathione S-transferase omega 1 inhibitor. Orally bioavailable.

Technical Data

M.Wt:
426.46
Formula:
C20H23N2NaO5S
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
256373-96-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc

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