CRID3 sodium salt

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CRID3 sodium salt | CAS No. 256373-96-3 | Inflammasomes Inhibitors
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Description: Potent NLRP3 inflammasome inhibitor; inhibits IL-1β production
Alternative Names: CP-456773, MCC 950

Chemical Name: N-[[(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-2-furansulfonamide sodium salt

Purity: ≥98%

Product Details
Citations (10)

Biological Activity

CRID3 sodium salt is a potent NLRP3 inflammasome inhibitor; closes the active conformation of NLRP3 to the inactive state. Directly interacts with the Walker B motif within the NLRP3 NACHT domain. Inhibits IL-1β, IL-18 and IL-1α production (IC50 values are 7.2, 10.3 and 12-18 nM, respectively). Selective for NLRP3 over NLRC4 inflammasome and Toll-like receptor signaling. Reduces severity of experimental autoimmune encephalomyelitis, skin inflammation and airway inflammation in mice. Also glutathione S-transferase omega 1 inhibitor. Orally bioavailable.

Technical Data

Soluble to 100 mM in water and to 100 mM in DMSO
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc

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Citations for CRID3 sodium salt

The citations listed below are publications that use Tocris products. Selected citations for CRID3 sodium salt include:

10 Citations: Showing 1 - 10

  1. Interleukin 38 alleviates aortic valve calcification by inhibition of NLRP3.
    Authors: David A Et al.
    Proc Natl Acad Sci U S A  2022;119:e2202577119
  2. Maternal P2X7 receptor inhibition prevents autism-like phenotype in male mouse offspring through the NLRP3-IL-1β pathway.
    Authors: Flóra Et al.
    Brain Behav Immun  2022;101:318-332
  3. An in vitro study of ApxI from Actinobacillus pleuropneumoniae serotype 10 and induction of NLRP3 inflammasome-dependent cell death.
    Authors: Eduardo Et al.
    Vet Rec Open  2021;8:e20
  4. Inhibition of the NLRP3 inflammasome by HSP90 inhibitors.
    Authors: Catherine B Et al.
    Immunology  2021;162:84-91
  5. CARD8 inflammasome activation triggers pyroptosis in human T cells.
    Authors: Oliver T Et al.
    EMBO J  2020;39:e105071
  6. Eldecalcitol Inhibits LPS-Induced NLRP3 Inflammasome-Dependent Pyroptosis in Human Gingival Fibroblasts by Activating the Nrf2/HO-1 Signaling Pathway.
    Authors: Minqi Et al.
    Drug Des Devel Ther  2020;14:4901-4913
  7. Inhibition of Amyloid-Beta Production, Associated Neuroinflammation, and Histone Deacetylase 2-Mediated Epigenetic Modifications Prevent Neuropathology in Alzheimer's Disease in vitro Model.
    Authors: Nagesh Et al.
    Front Aging Neurosci  2020;11:342
  8. Genetic and pharmacological inhibition of inflammasomes reduces the survival of Mycobacterium tuberculosis strains in macrophages.
    Authors: Nitya Et al.
    Sci Rep  2020;10:3709
  9. Enteropathogenic Escherichia coli Stimulates Effector-Driven Rapid Caspase-4 Activation in Human Macrophages.
    Authors: Goddard Et al.
    Cell Rep  2019;27:1008
  10. BAX/BAK-Induced Apoptosis Results in Caspase-8-Dependent IL-1β Maturation in Macrophages.
    Authors: Chauhan Et al.
    Cell Rep  2018;25:2354


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