CRID3 sodium salt
Chemical Name: N-[[(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-2-furansulfonamide sodium salt
Biological ActivityPotent NLRP3 inflammasome inhibitor; closes the active conformation of NLRP3 to the inactive state. Directly interacts with the Walker B motif within the NLRP3 NACHT domain. Inhibits IL-1β, IL-18 and IL-1α production (IC50 values are 7.2, 10.3 and 12-18 nM, respectively). Selective for NLRP3 over NLRC4 inflammasome and Toll-like receptor signaling. Reduces severity of experimental autoimmune encephalomyelitis, skin inflammation and airway inflammation in mice. Also glutathione S-transferase omega 1 inhibitor. Orally bioavailable.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases.
Coll et al.
Inflammasome inhibition prevents a-synuclein pathology and dopaminergic neurodegeneration in mice.
Gordon et al.
MCC950 closes the active conformation of NLRP3 to an inactive state.
Tapia-Abellán et al.
MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition.
Coll et al.
Glutathione S-transferase omega 1-1 is a target of cytokine release inhibitory drugs and may be responsible for their effect on interleukin-1β posttranslational processing.
Laliberte et al.
Citations for CRID3 sodium salt
The citations listed below are publications that use Tocris products. Selected citations for CRID3 sodium salt include:
2 Citations: Showing 1 - 2
Enteropathogenic Escherichia coli Stimulates Effector-Driven Rapid Caspase-4 Activation in Human Macrophages.
Authors: Goddard Et al.
Cell Rep 2019;27:1008
BAX/BAK-Induced Apoptosis Results in Caspase-8-Dependent IL-1β Maturation in Macrophages.
Authors: Chauhan Et al.
Cell Rep 2018;25:2354
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