Chemical Name: 4-[[5-[3-(2-Chloro-4-methylphenyl)-4-pyridinyl]-2-thiazolyl]amino]phenol
Biological ActivityCRT 0105950 is a potent LIMK1/2 inhibitor (IC50 values are 0.3 and 1 nM at LIMK 1 and 2, respectively). Disrupts microtubule organization, inhibits cofilin phosphorylation and increases α-tubulin acetylation in vitro.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Discovery, development, and SAR of aminothiazoles as LIMK inhibitors with cellular anti-invasive properties.
Charles et al.
LIM kinase inhibitors disrupt mitotic microtubule organization and impair tumor cell proliferation.
Mardilovich et al.
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