CRT 0105950 New
Chemical Name: 4-[[5-[3-(2-Chloro-4-methylphenyl)-4-pyridinyl]-2-thiazolyl]amino]phenol
Biological ActivityPotent LIMK1/2 inhibitor (IC50 values are 0.3 and 1 nM at LIMK 1 and 2, respectively). Disrupts microtubule organization, inhibits cofilin phosphorylation and increases α-tubulin acetylation in vitro.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Discovery, development, and SAR of aminothiazoles as LIMK inhibitors with cellular anti-invasive properties.
Charles et al.
LIM kinase inhibitors disrupt mitotic microtubule organization and impair tumor cell proliferation.
Mardilovich et al.
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