CST 967

Tocris Bioscience | Catalog # 7801

Potent and selective USP7 Degrader (PROTAC®)
Tocris Bioscience

Key Product Details

Description

Potent and selective USP7 Degrader (PROTAC®)
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Product Description

CST 967 is a potent and selective ubiquitin specific protease 7 (USP7) Degrader (PROTAC®; Dmax = 85% at 1μM, DC50 = 17 nM).

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Product Specifications for CST 967

Molecular Weight

927.07

Formula

C51H58N8O9

Storage

Store at -20°C

Purity

≥96% (HPLC)

Chemical Name

3-(1-(1-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidine-4-carbonyl)piperidin-4-yl)-N-(3-((4-hydroxy-1-((R)-3-phenylbutanoyl)piperidin-4-yl)methyl)-4-oxo-3,4-dihydroquinazolin-7-yl)propanamide

CAS Number

3093667-09-2

PubChem ID

170836153

InChI Key

REPLCRNGGWSKTN-JYQLQLLISA-N

SMILES

O=C1CCC(C(N1)=O)N2C(C3=C(C2=O)C=CC(N4CCC(CC4)C(N5CCC(CC5)CCC(NC6=CC(N=CN7CC8(CCN(CC8)C(C[C@H](C9=CC=CC=C9)C)=O)O)=C(C=C6)C7=O)=O)=O)=C3)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 92.71 100

Preparing Stock Solutions for CST 967

The following data is based on the product molecular weight 927.07.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.08 mL 5.39 mL 10.79 mL
5 mM 0.22 mL 1.08 mL 2.16 mL
10 mM 0.11 mL 0.54 mL 1.08 mL
50 mM 0.02 mL 0.11 mL 0.22 mL

Calculators

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

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Background References

References are publications that support the biological activity of the product.

Product Documents for CST 967

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for CST 967

For research use only

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