Catalog Number: 4726
Chemical Name: 1,5-Dihydro-7-(phenylmethyl)-1-[3-(1-piperidinyl)propyl]-2-[4-(4-pyridinyl)phenyl]-6H-imidazo[4,5-g]quinoxalin-6-one
Biological Activity
Interleukin-2-inducible T-cell kinase (ITK) inhibitor (IC50 values are 0.1, 0.4 and 5 μM for ITK, BTK and ETK, respectively). Inhibits growth of cancer cells expressing ITK, including MOLT-4 and Jurkat cells in vitro. Induces apoptosis in Jurkat cells. Inhibits MOLT-4 xenograft tumor growth in mice.
Technical Data
  • M.Wt:
    554.68
  • Formula:
    C35H34N6O
  • Solubility:
    Soluble to 10 mM in DMSO with gentle warming
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    1265822-30-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Molecular characteristics of CTA056, a novel interleukin-2-inducible T-cell kinase inhibitor that selectively targets malignant T cells and modulates oncomirs.
    Guo et al.
    Mol.Pharmacol., 2012;82:938

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