Interleukin-2-inducible T-cell kinase (ITK) inhibitor (IC50
values are 0.1, 0.4 and 5 μ
M for ITK, BTK and ETK, respectively). Inhibits growth of cancer cells expressing ITK, including MOLT-4 and Jurkat cells in vitro
. Induces apoptosis in Jurkat cells. Inhibits MOLT-4 xenograft tumor growth in mice.
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All Tocris products are intended for laboratory research use only.
Molecular characteristics of CTA056, a novel interleukin-2-inducible T-cell kinase inhibitor that selectively targets malignant T cells and modulates oncomirs.
Guo et al.