CTA 056

Catalog # Availability Size / Price Qty
4726/2
CTA 056 | CAS No. 1265822-30-7 | ITK Inhibitors
1 Image
Description: ITK inhibitor

Chemical Name: 1,5-Dihydro-7-(phenylmethyl)-1-[3-(1-piperidinyl)propyl]-2-[4-(4-pyridinyl)phenyl]-6H-imidazo[4,5-g]quinoxalin-6-one

Purity: ≥98%

Product Details
Citations (1)
Reviews (1)

Biological Activity

CTA 056 is an interleukin-2-inducible T-cell kinase (ITK) inhibitor (IC50 values are 0.1, 0.4 and 5 μM for ITK, BTK and ETK, respectively). Inhibits growth of cancer cells expressing ITK, including MOLT-4 and Jurkat cells in vitro. Induces apoptosis in Jurkat cells. Inhibits MOLT-4 xenograft tumor growth in mice.

Technical Data

M.Wt:
554.68
Formula:
C35H34N6O
Solubility:
Soluble to 10 mM in DMSO with gentle warming
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1265822-30-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for CTA 056

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T-ALL Network and Pharmacological Validation of Synthetic Lethal Screen
By Anonymous on 03/26/2020
Application: Species: Human

10uM

PMID: 30970263

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