Catalog # Availability Size / Price Qty
Cat.No. 4884 - CU CPT 22 | C19H22O7 | CAS No. 1416324-85-0
1 Image
Description: Selective TLR1/2 inhibitor

Chemical Name: 3,4,6-Trihydroxy-2-methoxy-5-oxo-5H-benzocycloheptene-8-carboxylic acid hexyl ester

Product Details
Citations (1)
Supplemental Products

Biological Activity

Selective toll-like receptor 1/2 (TLR1/2) inhibitor (IC50 = 0.58 μM). Exhibits no activity at TLR2/TLR6, TLR3, TLR4 and TLR7 or a panel of 10 representative kinases. Inhibits the release of proinflammatory cytokines TNF-α and IL-1β.

Technical Data

Soluble to 100 mM in DMSO and to 50 mM in ethanol
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Additional Information

Licensing Caveats:
Sold under license from the University of Colorado

Background References

  1. Discovery of small-molecule inhibitors of the TLR1/TLR2 complex.
    Cheng et al.
    Angew Chem.Int.Ed.Engl., 2012;51:12246

Product Datasheets

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Citation for CU CPT 22

The citations listed below are publications that use Tocris products. Selected citations for CU CPT 22 include:

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