CU CPT 22
Chemical Name: 3,4,6-Trihydroxy-2-methoxy-5-oxo-5H-benzocycloheptene-8-carboxylic acid hexyl ester
Biological ActivitySelective toll-like receptor 1/2 (TLR1/2) inhibitor (IC50 = 0.58 μM). Exhibits no activity at TLR2/TLR6, TLR3, TLR4 and TLR7 or a panel of 10 representative kinases. Inhibits the release of proinflammatory cytokines TNF-α and IL-1β.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Discovery of small-molecule inhibitors of the TLR1/TLR2 complex.
Cheng et al.
Angew Chem.Int.Ed.Engl., 2012;51:12246
Citations for CU CPT 22
The citations listed below are publications that use Tocris products. Selected citations for CU CPT 22 include:
2 Citations: Showing 1 - 2
Nonsaponin fraction of Korean Red Ginseng attenuates cytokine production via inhibition of TLR4 expression.
Authors: Ahn Et al.
J Ginseng Res 2019;43:291
Inflammasome priming is similar for francisella species that differentially induce inflammasome activation.
Authors: Ghonime Et al.
Nucleic Acids Res 2015;10:e0127278
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VersaClone cDNA Plasmids
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