CU CPT 22

Catalog # Availability Size / Price Qty
4884/10
4884/50
Toll-like Receptor Inhibitors Small Molecule
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Description: Selective TLR1/2 inhibitor

Chemical Name: 3,4,6-Trihydroxy-2-methoxy-5-oxo-5H-benzocycloheptene-8-carboxylic acid hexyl ester

Purity: ≥98%

Product Details
Citations (1)
Supplemental Products
Reviews

Biological Activity

Selective toll-like receptor 1/2 (TLR1/2) inhibitor (IC50 = 0.58 μM). Exhibits no activity at TLR2/TLR6, TLR3, TLR4 and TLR7 or a panel of 10 representative kinases. Inhibits the release of proinflammatory cytokines TNF-α and IL-1β.

Technical Data

M.Wt:
362.37
Formula:
C19H22O7
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1416324-85-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from the University of Colorado

Background References

  1. Discovery of small-molecule inhibitors of the TLR1/TLR2 complex.
    Cheng et al.
    Angew Chem.Int.Ed.Engl., 2012;51:12246

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Citation for CU CPT 22

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