Selective toll-like receptor 1/2 (TLR1/2) inhibitor (IC50
= 0.58 μ
M). Exhibits no activity at TLR2/TLR6, TLR3, TLR4 and TLR7 or a panel of 10 representative kinases. Inhibits the release of proinflammatory cytokines TNF-α
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Sold under license from the University of Colorado
Discovery of small-molecule inhibitors of the TLR1/TLR2 complex.
Cheng et al.
Angew Chem.Int.Ed.Engl., 2012;51:12246
The citations listed below are publications that use Tocris products. Selected citations for CU CPT 22 include:
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