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CU CPT 22

Catalog #: 4884
2 Citations Datasheet / COA / SDS
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4884/10
4884/50
CU CPT 22 | CAS No. 1416324-85-0 | Toll-like Receptor Inhibitors
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Description: Selective TLR1/2 inhibitor

Chemical Name: 3,4,6-Trihydroxy-2-methoxy-5-oxo-5H-benzocycloheptene-8-carboxylic acid hexyl ester

Purity: ≥98%

Product Details
Citations (2)
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Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

CU CPT 22 is a selective toll-like receptor 1/2 (TLR1/2) inhibitor (IC50 = 0.58 μM). Exhibits no activity at TLR2/TLR6, TLR3, TLR4 and TLR7 or a panel of 10 representative kinases. Inhibits the release of proinflammatory cytokines TNF-α and IL-1β.

Technical Data

M.Wt:
362.37
Formula:
C19H22O7
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1416324-85-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from the University of Colorado

Background References

  1. Discovery of small-molecule inhibitors of the TLR1/TLR2 complex.
    Cheng et al.
    Angew Chem.Int.Ed.Engl., 2012;51:12246

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Citations for CU CPT 22

The citations listed below are publications that use Tocris products. Selected citations for CU CPT 22 include:

2 Citations: Showing 1 - 2

  1. Nonsaponin fraction of Korean Red Ginseng attenuates cytokine production via inhibition of TLR4 expression.
    Authors: Ahn Et al.
    J Ginseng Res  2019;43:291
  2. Inflammasome priming is similar for francisella species that differentially induce inflammasome activation.
    Authors: Ghonime Et al.
    Nucleic Acids Res  2015;10:e0127278

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VersaClone cDNA Plasmids

Human TLR1 (NP_003254) VersaClone cDNA

RDC0442

Human TLR2 (NP_003255) VersaClone cDNA

RDC0370

Mouse TLR1 (NP_109607) VersaClone cDNA

RDC0613

Mouse TLR2 (NP_036035) VersaClone cDNA

RDC0642

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