Biological Activity Selective TLR3 inhibitor (IC50 = 3.44 μM in RAW 264.7 cells); suppresses downstream signaling pathways mediated by the TLR3/dsRNA complex, inhibiting TNF-α and IL-1β production in whole cells. Reduces death of crypt cells and improves gastrointestinal syndrome in mice.
Soluble to 100 mM in DMSO and to 50 mM in 1eq. NaOH
Store at +4°C
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Sold under license from the University of Colorado
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