CU CPT 4a

Key Product Details

Product Description

CU CPT 4a is a selective TLR3 inhibitor (IC₅₀ = 3.44 μM in RAW 264.7 cells); suppresses downstream signaling pathways mediated by the TLR3/dsRNA complex, inhibiting TNF-α and IL-1β production in whole cells. Reduces death of crypt cells and improves gastrointestinal syndrome in mice.

Licensing Information

Sold under license from the University of Colorado

Product Specifications for CU CPT 4a

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for CU CPT 4a

The following data is based on the product molecular weight 377.82.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.65 mL	13.23 mL	26.47 mL
5 mM	0.53 mL	2.65 mL	5.29 mL
10 mM	0.26 mL	1.32 mL	2.65 mL
50 mM	0.05 mL	0.26 mL	0.53 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 14 publications citing the usage of this product.

• Takemura Blockade of TLR3 protects mice from lethal radiation-induced gastrointestinal syndrome. Nat.Commun. 2014 PMID: 24637670
• Cheng Small-molecule inhibitors of the TLR3/dsRNA complex. J.Am.Chem.Soc. 2011 PMID: 21355588

Product Documents for CU CPT 4a