CU CPT 9a
Chemical Name: 2-Methyl-4-(7-methoxy-4-quinolinyl)phenol
Biological ActivityPotent TLR8 inhibitor (IC50 = 0.5 nM and Kd = 21 nM). Stabilizes the TLR8 dimer in its resting state, preventing activation. Suppresses TLR8-mediated proinflammatory signaling in various cell lines and human primary cells.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Small-molecule inhibition of TLR8 through stabilization of its resting state.
Zhang et al.
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