CU CPT 9a

Catalog # Availability Size / Price Qty
6479/5
6479/25
Cat.No. 6479 - CU CPT 9a | C17H15NO2 | CAS No. 2165340-32-7
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Description: Potent TLR8 inhibitor

Chemical Name: 2-Methyl-4-(7-methoxy-4-quinolinyl)phenol

Purity: ≥98%

Product Details
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Biological Activity

Potent TLR8 inhibitor (IC50 = 0.5 nM and Kd = 21 nM). Stabilizes the TLR8 dimer in its resting state, preventing activation. Suppresses TLR8-mediated proinflammatory signaling in various cell lines and human primary cells.

Technical Data

M.Wt:
265.31
Formula:
C17H15NO2
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2165340-32-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Additional Information

Licensing Caveats:
Sold under license from the University of Colorado

Background References

  1. Small-molecule inhibition of TLR8 through stabilization of its resting state.
    Zhang et al.
    Nat.Chem.Biol., 2018;14:58

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