CU CPT 9a

Key Product Details

Product Description

CU CPT 9a is a potent TLR8 inhibitor (IC₅₀ = 0.5 nM and K_d = 21 nM). Stabilizes the TLR8 dimer in its resting state, preventing activation. Suppresses TLR8-mediated proinflammatory signaling in various cell lines and human primary cells.

Licensing Information

Sold under license from the University of Colorado

Product Specifications for CU CPT 9a

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for CU CPT 9a

The following data is based on the product molecular weight 265.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.77 mL	18.85 mL	37.69 mL
5 mM	0.75 mL	3.77 mL	7.54 mL
10 mM	0.38 mL	1.88 mL	3.77 mL
50 mM	0.08 mL	0.38 mL	0.75 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Zhang Small-molecule inhibition of TLR8 through stabilization of its resting state. Nat.Chem.Biol. 2018 PMID: 29155428

Product Documents for CU CPT 9a