CU CPT 9a
Chemical Name: 2-Methyl-4-(7-methoxy-4-quinolinyl)phenol
Biological ActivityPotent TLR8 inhibitor (IC50 = 0.5 nM and Kd = 21 nM). Stabilizes the TLR8 dimer in its resting state, preventing activation. Suppresses TLR8-mediated proinflammatory signaling in various cell lines and human primary cells.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Small-molecule inhibition of TLR8 through stabilization of its resting state.
Zhang et al.
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