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CU-T12-9

5414 1 Review Datasheet / COA / SDS
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5414/50
5414/10
CU-T12-9 | CAS No. 1821387-73-8 | Toll-like Receptor Agonists
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Description: Potent TLR1/2 agonist

Chemical Name: N-Methyl-4-nitro-2-(4-(4-trifluoromethyl)phenyl)-1H-imidazol-1-yl)aniline

Purity: ≥99%

Product Details
Supplemental Products
Reviews (1)
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

CU-T12-9 is a potent TLR1/2 agonist (EC50 = 52.9 nM). Activates the NF-κB pathway and upregulates proinflammatory cytokines in vitro. Also enhances TLR1 and TLR2 dimerization.

Technical Data

M.Wt:
362.31
Formula:
C17H13F3N4O2
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
1821387-73-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from the University of Colorado

Background References

  1. Specific activation of the TLR1-TLR2 heterodimer by small-molecule agonists
    Cheng et al.
    Sci.Adv., 2015;1:e1400139
  2. Discovery of small molecule inhibitors of the TLR1-TLR2 complex.
    Cheng et al.
    Angew.Chem.Int.Ed.Engl., 2013;51:12246

Product Datasheets

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VersaClone cDNA Plasmids

Human TLR1 (NP_003254) VersaClone cDNA

RDC0442

Human TLR2 (NP_003255) VersaClone cDNA

RDC0370

Mouse TLR1 (NP_109607) VersaClone cDNA

RDC0613

Mouse TLR2 (NP_036035) VersaClone cDNA

RDC0642

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activation of NF-kappa B pathway in presence of CUt-12-9
By Tahmineh Safaie on 02/28/2020
Application: Species: Mouse

Raw-Blue cell lines were treated with different concentration of CU-T129 for 24 hours and the level of Seap was measured

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