CU-T12-9

Catalog # Availability Size / Price Qty
5414/50
5414/10
Toll-like Receptor Agonists Small Molecule
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Description: Potent TLR1/2 agonist

Chemical Name: N-Methyl-4-nitro-2-(4-(4-trifluoromethyl)phenyl)-1H-imidazol-1-yl)aniline

Purity: ≥99%

Product Details
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Biological Activity

Potent TLR1/2 agonist (EC50 = 52.9 nM). Activates the NF-κB pathway and upregulates proinflammatory cytokines in vitro. Also enhances TLR1 and TLR2 dimerization.

Technical Data

M.Wt:
362.31
Formula:
C17H13F3N4O2
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
≥99%
Storage:
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from the University of Colorado

Background References

  1. Specific activation of the TLR1-TLR2 heterodimer by small-molecule agonists
    Cheng et al.
    Sci.Adv., 2015;1:e1400139
  2. Discovery of small molecule inhibitors of the TLR1-TLR2 complex.
    Cheng et al.
    Angew.Chem.Int.Ed.Engl., 2013;51:12246

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