CU-T12-9
Chemical Name: N-Methyl-4-nitro-2-(4-(4-trifluoromethyl)phenyl)-1H-imidazol-1-yl)aniline
Purity: ≥99%
Biological Activity
Potent TLR1/2 agonist (EC50 = 52.9 nM). Activates the NF-κB pathway and upregulates proinflammatory cytokines in vitro. Also enhances TLR1 and TLR2 dimerization.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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Specific activation of the TLR1-TLR2 heterodimer by small-molecule agonists
Cheng et al.
Sci.Adv., 2015;1:e1400139 -
Discovery of small molecule inhibitors of the TLR1-TLR2 complex.
Cheng et al.
Angew.Chem.Int.Ed.Engl., 2013;51:12246
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Raw-Blue cell lines were treated with different concentration of CU-T129 for 24 hours and the level of Seap was measured