Cucurbitacin I

Catalog # Availability Size / Price Qty
1571/1
Cucurbitacin I | CAS No. 2222-07-3 | JAK Kinase Inhibitors
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Description: Selective inhibitor of STAT3/JAK2 signaling
Alternative Names: Elatericin B, JSI 124

Chemical Name: (9β,10α,16α,23E)-2,16,20,25-Tetrahydroxy-9-methyl-19-norlanosta-1,5,23-triene-3,11,22-trione

Purity: ≥95%

Product Details
Citations (8)
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Reviews

Biological Activity

Selective inhibitor of STAT3/JAK2 signaling. Inhibits the activation of STAT3 and JAK2 and displays no activity on Src, Akt, ERK and JNK. Suppresses phosphotyrosine levels of STAT3, inhibits STAT3 DNA binding and STAT3-mediated gene expression. Induces apoptosis in cell lines expressing constitutively active tyrosine-phosphorylated STAT3.

Technical Data

M.Wt:
514.65
Formula:
C30H42O7
Solubility:
Soluble to 10 mM in DMSO and to 20 mM in ethanol
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
2222-07-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Cucurbitacin I

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8 Citations: Showing 1 - 8

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