Cucurbitacin I

Key Product Details

Product Description

Cucurbitacin I is a selective inhibitor of STAT3/JAK2 signaling. Inhibits the activation of STAT3 and JAK2 and displays no activity on Src, Akt, ERK and JNK. Suppresses phosphotyrosine levels of STAT3, inhibits STAT3 DNA binding and STAT3-mediated gene expression. Induces apoptosis in cell lines expressing constitutively active tyrosine-phosphorylated STAT3.

Product Specifications for Cucurbitacin I

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Cucurbitacin I

The following data is based on the product molecular weight 514.65.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.43 mL	97.15 mL	194.31 mL
0.5 mM	3.89 mL	19.43 mL	38.86 mL
1 mM	1.94 mL	9.72 mL	19.43 mL
5 mM	0.39 mL	1.94 mL	3.89 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 22 publications citing the usage of this product.

• Nefedova Regulation of dendritic cell differentiation and antitumor immune response in cancer by pharmacologic-selective inhibition of the janus-activated kinase 2/signal transducers and activators of transcription 3 pathway. Cancer Res. 2005 PMID: 16230418
• Dziennis Role of signal transducer and activator of transcription-3 in OE-mediated neuroprotection. J.Neurosci. 2007 PMID: 17611279
• Blaskovich Discovery of JSI-124 (cucurbitacin I), a selective janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice. Cancer Res. 2003 PMID: 12649187

Product Documents for Cucurbitacin I