Catalog Number: 1571
Alternate Names: Elatericin B, JSI 124
Chemical Name: (9β,10α,16α,23E)-2,16,20,25-Tetrahydroxy-9-methyl-19-norlanosta-1,5,23-triene-3,11,22-trione
Biological Activity
Selective inhibitor of STAT3/JAK2 signaling. Inhibits the activation of STAT3 and JAK2 and displays no activity on Src, Akt, ERK and JNK. Suppresses phosphotyrosine levels of STAT3, inhibits STAT3 DNA binding and STAT3-mediated gene expression. Induces apoptosis in cell lines expressing constitutively active tyrosine-phosphorylated STAT3.
Technical Data
  • M.Wt:
    514.65
  • Formula:
    C30H42O7
  • Solubility:
    Soluble to 10 mM in DMSO and to 20 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    2222-07-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Discovery of JSI-124 (cucurbitacin I), a selective janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice.
    Blaskovich et al.
    Cancer Res., 2003;63:1270
  2. Regulation of dendritic cell differentiation and antitumor immune response in cancer by pharmacologic-selective inhibition of the janus-activated kinase 2/signal transducers and activators of transcription 3 pathway.
    Nefedova et al.
    Cancer Res., 2005;65:9525
  3. Role of signal transducer and activator of transcription-3 in estradiol-mediated neuroprotection.
    Dziennis et al.
    J.Neurosci., 2007;27:7268
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Cucurbitacin I include:

4 Citations: Showing 1 - 4
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  1. Upregulation of Nicotinic Acetylcholine Receptor α4+β2 through a Ligand-Independent PI3Kβ Mechanism That Is Enhanced by TNFα and the Jak2/p38Mapk Pathways.
    Authors: Rogers and Gahring
    Cell Rep 2015;10:e0143319
  2. Retinal injury, growth factors, and cytokines converge on β-catenin and pStat3 signaling to stimulate retina regeneration.
    Authors: Wan Et al.
    J Neurosci 2014;9:285
  3. On-target JAK2/STAT3 inhibition slows disease progression in orthotopic xenografts of human glioblastoma brain tumor stem cells.
    Authors: Stechishin Et al.
    Neuro Oncol 2013;15:198
  4. Cytokine induction of tumor necrosis factor receptor 2 is mediated by STAT3 in colon cancer cells.
    Authors: Hamilton Et al.
    Mol Cancer Res 2011;9:1718

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