Chemical Name: (9β,10α,16α,23E)-2,16,20,25-Tetrahydroxy-9-methyl-19-norlanosta-1,5,23-triene-3,11,22-trione
Biological ActivityCucurbitacin I is a selective inhibitor of STAT3/JAK2 signaling. Inhibits the activation of STAT3 and JAK2 and displays no activity on Src, Akt, ERK and JNK. Suppresses phosphotyrosine levels of STAT3, inhibits STAT3 DNA binding and STAT3-mediated gene expression. Induces apoptosis in cell lines expressing constitutively active tyrosine-phosphorylated STAT3.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Regulation of dendritic cell differentiation and antitumor immune response in cancer by pharmacologic-selective inhibition of the janus-activated kinase 2/signal transducers and activators of transcription 3 pathway.
Nefedova et al.
Cancer Res., 2005;65:9525
Role of signal transducer and activator of transcription-3 in OE-mediated neuroprotection.
Dziennis et al.
Discovery of JSI-124 (cucurbitacin I), a selective janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice.
Blaskovich et al.
Cancer Res., 2003;63:1270
Citations for Cucurbitacin I
The citations listed below are publications that use Tocris products. Selected citations for Cucurbitacin I include:
8 Citations: Showing 1 - 8
Butyrate Produced by Commensal Bacteria Down-Regulates Indolamine 2,3-Dioxygenase 1 (IDO-1) Expression via a Dual Mechanism in Human Intestinal Epithelial Cells.
Authors: Martin-Gallausiaux Et al.
Front Immunol 2019;9:2838
Crosstalk between bone marrow-derived myofibroblasts and gastric cancer cells regulates cancer stemness and promotes tumorigenesis.
Authors: Zhu Et al.
Upregulation of Nicotinic Acetylcholine Receptor α4+β2 through a Ligand-Independent PI3Kβ Mechanism That Is Enhanced by TNFα and the Jak2/p38Mapk Pathways.
Authors: Rogers and Gahring
Cell Rep 2015;10:e0143319
Retinal injury, growth factors, and cytokines converge on β-catenin and pStat3 signaling to stimulate retina regeneration.
Authors: Wan Et al.
J Neurosci 2014;9:285
On-target JAK2/STAT3 inhibition slows disease progression in orthotopic xenografts of human glioblastoma brain tumor stem cells.
Authors: Stechishin Et al.
Neuro Oncol 2013;15:198
Cytokine induction of tumor necrosis factor receptor 2 is mediated by STAT3 in colon cancer cells.
Authors: Hamilton Et al.
Mol Cancer Res 2011;9:1718
The histone deacetylase inhibitors vorin. and romid. downmodulate IL-10 expression in cutaneous T-cell lymphoma cells.
Authors: Tiffon Et al.
Br J Pharmacol 2011;162:1590
Balancing inflammation and tolerance in vivo through dendritic cells by the commensal Candida albicans.
Authors: Bonifazi Et al.
Mucosal Immunol 2009;2:362
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