Cultrex Stem Cell Qualified Human Fibronectin, PathClear
Cultrex Stem Cell Qualified Human Fibronectin, PathClear Summary
Cultrex Stem Cell Qualified Human Fibronectin, Pathclear is a purified stromal extracellular matrix protein that provides a functionally defined and effective feeder-free surface for the attachment and maintenance of pluripotent stem cells in culture.Key Benefits
• Qualified as a substrate for pluripotent stem cells
• Promotes a feeder-free culture
• Pathclear-tested to ensure product is free of human virus and pathogens
• Source tissue is LDEV-free
Why Use Cultrex Stem Cell Qualified Human Fibronectin?
Cultrex Stem Cell Qualified Human Fibronectin, Pathclear is purified from human plasma and is Pathclear certified to be free of common pathogens. Fibronectin is an extracellular matrix protein that is found abundantly in blood and connective tissues. These matrices are associated with the epithelial to mesenchymal transition of metastatic cells, including tumor cells with stem cell-like properties. Fibronectin performs essential functions in collagen fibrillogenesis, as either a general cell adhesion molecule or a modulator in binding between cell surfaces and the extracellular matrix. Fibronectin matrix assembly is essential for normal vertebrate development and apparently contributes to the generation of tumor metastases by supporting the establishment and persistence of pre-metastatic niches. Fibronectin is secreted as a disulfide-linked dimer of 230-270 kDa, comprised of three types of repeating modules that mediate interactions with extracellular matrix components (including fibronectin itself), and cells via integrins and other fibronectin receptors. Thus, fibronectin can be used for coating tissue culture surfaces or as a medium additive to promote stem cell adhesion and proliferation. It is 0.2 μm sterile filtered.
Specifications
Limitations
For research use only. Not for diagnostic use.
Product Datasheets
Complete Your Research
Citation for Cultrex Stem Cell Qualified Human Fibronectin, PathClear
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
1 Citation: Showing 1 - 1
-
3D spheroid models of paediatric SHH medulloblastoma mimic tumour biology, drug response and metastatic dissemination
Authors: SJ Roper, F Linke, PJ Scotting, B Coyle
Scientific Reports, 2021;11(1):4259. 2021
FAQs
No product specific FAQs exist for this product, however you may
View all FAQsReviews for Cultrex Stem Cell Qualified Human Fibronectin, PathClear
There are currently no reviews for this product. Be the first to review Cultrex Stem Cell Qualified Human Fibronectin, PathClear and earn rewards!
Have you used Cultrex Stem Cell Qualified Human Fibronectin, PathClear?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image