Cultrex Stem Cell Qualified Human Fibronectin, PathClear
Cultrex Stem Cell Qualified Human Fibronectin, PathClear Summary
• Qualified as a substrate for pluripotent stem cells
• Promotes a feeder-free culture
• Pathclear-tested to ensure product is free of human virus and pathogens
• Source tissue is LDEV-free
Why Use Cultrex Stem Cell Qualified Human Fibronectin?
Cultrex Stem Cell Qualified Human Fibronectin, Pathclear is purified from human plasma and is Pathclear certified to be free of common pathogens. Fibronectin is an extracellular matrix protein that is found abundantly in blood and connective tissues. These matrices are associated with the epithelial to mesenchymal transition of metastatic cells, including tumor cells with stem cell-like properties. Fibronectin performs essential functions in collagen fibrillogenesis, as either a general cell adhesion molecule or a modulator in binding between cell surfaces and the extracellular matrix. Fibronectin matrix assembly is essential for normal vertebrate development and apparently contributes to the generation of tumor metastases by supporting the establishment and persistence of pre-metastatic niches. Fibronectin is secreted as a disulfide-linked dimer of 230-270 kDa, comprised of three types of repeating modules that mediate interactions with extracellular matrix components (including fibronectin itself), and cells via integrins and other fibronectin receptors. Thus, fibronectin can be used for coating tissue culture surfaces or as a medium additive to promote stem cell adhesion and proliferation. It is 0.2 μm sterile filtered.
For research use only. Not for diagnostic use.
Citation for Cultrex Stem Cell Qualified Human Fibronectin, PathClear
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
1 Citation: Showing 1 - 1
3D spheroid models of paediatric SHH medulloblastoma mimic tumour biology, drug response and metastatic dissemination
Authors: SJ Roper, F Linke, PJ Scotting, B Coyle
Scientific Reports, 2021;11(1):4259. 2021
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