Mesenchymal Stem Cell Differentiation Pathways & Lineage-specific Markers

Click on a cell type below to view a subset of molecules used as markers for the identification of that cell type.

Mesenchymal
Stem Cells
Mesenchymal
Stem Cells
Noggin
Noggin
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BMP-2, 4
BMP-2, 4
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Insulin
Insulin
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Wnt-5b
Wnt-5b
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Adipogenesis
Induction
Media
Adipogenesis
Induction
Media
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White
Pre-Adipocytes
White
Pre-Adipocytes
BMP-2, 4
BMP-2, 4
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Insulin
Insulin
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Noggin
Noggin
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White
Adipocytes
White
Adipocytes
FGF basic
FGF basic
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TGF-Beta
TGF-Beta
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Myogenic
Precursors
Myogenic
Precursors
BMP-7
BMP-7
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Brown
Pre-Adipocytes
Brown
Pre-Adipocytes
BMP-7
BMP-7
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Brown
Adipocytes
Brown
Adipocytes
FGF basic
FGF basic
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TGF-Beta
TGF-Beta
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Myoblasts
Myoblasts
PDGF-BB
PDGF-BB
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Wnt-4, 7b
Wnt-4, 7b
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Skeletal
Muscle
Skeletal
Muscle
BMP-4
BMP-4
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FGF basic
FGF basic
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FGF-4, 8
FGF-4, 8
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Cardiac
Muscle
Cardiac
Muscle
Wnt-4, 7b
Wnt-4, 7b
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Smooth
Muscle
Smooth
Muscle
BMP-5
BMP-5
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FGF basic
FGF basic
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FGF-4, 8, 10
FGF-4, 8, 10
TGF-Beta 1, 2
TGF-Beta 1, 2
N-Cadherin
N-Cadherin
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NCAM-1/CD56
NCAM-1/CD56
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Perlecan
Perlecan
Veriscan
Veriscan
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Chondrogenesis
Induction
Media
Chondrogenesis
Induction
Media
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Condensing
Mesenchymal
Stem Cells
Condensing
Mesenchymal
Stem Cells
BMP-2, 4, 5, 7
BMP-2, 4, 5, 7
GDF-5/BMP-14
GDF-5/BMP-14
TGF-Beta 1, 2, 3
TGF-Beta 1, 2, 3
FGF basic
FGF basic
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IGF-1
IGF-1
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Chondrocytes
Chondrocytes
BMP-2
BMP-2
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PTH
PTH
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TGF-Beta
TGF-Beta
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Wnt-10b
Wnt-10b
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Osteogenesis
Induction
Media
Osteogenesis
Induction
Media
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Osteoblast
Progenitors
Osteoblast
Progenitors
BMP-2, 4, 6
BMP-2, 4, 6
PTH
PTH
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FGF basic
FGF basic
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IGF-1
IGF-1
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Wnt-10b
Wnt-10b
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Vitamin D3
Vitamin D3
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Mature
Osteoblasts
Mature
Osteoblasts
Self-renewal factors
Self-renewal factors

Overview of Mesenchymal Stem Cells & Lineage-specific Markers

Mesenchymal stem cells (MSCs) are defined as multipotent, self-renewing progenitors that can be differentiated into adipocytes, chondrocytes, and osteocytes. Originally identified in mouse bone marrow, MSCs have now been discovered in a variety of species and isolated from numerous tissues including adipose, placental, dental pulp, and umbilical cord. Despite the classical trilineage differentiation that functionally identifies MSCs, these cells have also been shown to differentiate into non-traditional lineages to produce cardiomyocytes, endothelial cells, hepatocytes, and neural cells. To date, the biological properties of MSC identification, differentiation, and function have yet to be confirmed in vivo, raising caution for the extrapolation of in vitro generated data. The mechanisms controlling MSC self-renewal and differentiation are thought to be influenced by a diverse set of growth factors, receptors, intracellular signaling molecules, and transcription factors. The factors depicted below are known to influence MSC multipotency, proliferation, and lineage commitment. MSCs and their differentiated progeny can be identified by the expression of a unique combination of cell surface markers and transcription factors. Unique identifiers for each cell can be viewed by clicking on that cell-type within the lineage pathway.

To learn more, please visit our Mesenchymal Stem Cells Research Area.

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