Potent and selective, reversible inhibitor of aldehyde dehydrogenase 2 (ALDH2) (IC50
values are 29 and 1300 nM for ALDH2 and ALDH1, respectively). Exhibits anxiolytic effects in rat models.
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A selective ALDH-2 inhibitor reduces anxiety in rats.
Overstreet et al.
Inhibition of aldehyde dehydrogenase-2 suppresses cocaine seeking by generating THP, a cocaine use-dependent inhibitor of dopamine synthesis.
Yao et al.