Catalog Number: 5164
Chemical Name: 3-[[[3-[4-[(Methylsulfonyl)amino]phenyl]-4-oxo-4H-1-benzopyran-7-yl]oxy]methyl]benzoic acid
Biological Activity
Potent and selective, reversible inhibitor of aldehyde dehydrogenase 2 (ALDH2) (IC50 values are 29 and 1300 nM for ALDH2 and ALDH1, respectively). Exhibits anxiolytic effects in rat models.
Technical Data
  • M.Wt:
    465.48
  • Formula:
    C24H19NO7S
  • Solubility:
    Soluble to 100 mM in DMSO and to 50 mM in 1eq. NaOH
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    1005334-57-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. A selective ALDH-2 inhibitor reduces anxiety in rats.
    Overstreet et al.
    Pharmacol.Biochem.Behav., 2009;94:255
  2. Inhibition of aldehyde dehydrogenase-2 suppresses cocaine seeking by generating THP, a cocaine use-dependent inhibitor of dopamine synthesis.
    Yao et al.
    Nat.Med., 2010;16:1024

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