CVT 313 (CAS 199986-75-9): R&D Systems
Catalog Number: 6174
Chemical Name: 2,2'-[[6-[[(4-Methoxyphenyl)methyl]amino]-9-(1-methylethyl)-9H-purin-2-yl]imino]bis[ethanol]
Biological Activity
cdk2 inhibitor (IC50 = 0.5 μM). Exhibits >8-fold selectivity for CDK2 over CDK1 and CDK4 (IC50 values are 4.2 and 215 μM, respectively). Inhibits proliferation rat neonatal aortic smooth muscle cells and a range of tumor cells lines in vitro. Inhibits restenosis in a rat carotid artery injury model.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. CVT-313, a specific and potent inhibitor of CDK2 that prevents neointimal proliferation.
    Brooks et al.
    J.Biol.Chem., 1997;272:29207
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