Biological Activity cdk2 inhibitor (IC50 = 0.5 μM). Exhibits >8-fold selectivity for CDK2 over CDK1 and CDK4 (IC50 values are 4.2 and 215 μM, respectively). Inhibits proliferation rat neonatal aortic smooth muscle cells and a range of tumor cells lines in vitro. Inhibits restenosis in a rat carotid artery injury model.
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Store at -20°C
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