cdk2 inhibitor (IC50
= 0.5 μM). Exhibits >8-fold selectivity for CDK2 over CDK1 and CDK4 (IC50
values are 4.2 and 215 μM, respectively). Inhibits proliferation rat neonatal aortic smooth muscle cells and a range of tumor cells lines in vitro
. Inhibits restenosis in a rat carotid artery injury model.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
CVT-313, a specific and potent inhibitor of CDK2 that prevents neointimal proliferation.
Brooks et al.