Chemical Name: 2,2'-[[6-[[(4-Methoxyphenyl)methyl]amino]-9-(1-methylethyl)-9H-purin-2-yl]imino]bis[ethanol]
Biological ActivityCVT 313 is a cyclin-dependent kinase 2 (cdk2) inhibitor (reported IC50 values are 0.18 to 0.5 μM). Also inhibits cdk5 in sub-micromolar range (IC50 = 0.42 μM). Displays >7-fold selectivity for cdk2 and cdk5 over other cdks. Inhibits proliferation rat neonatal aortic smooth muscle cells and a range of tumor cells lines in vitro. Inhibits restenosis in a rat carotid artery injury model.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
CVT-313, a specific and potent inhibitor of CDK2 that prevents neointimal proliferation.
Brooks et al.
How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases?
Jorda et al.
Citation for CVT 313
The citations listed below are publications that use Tocris products. Selected citations for CVT 313 include:
1 Citation: Showing 1 - 1
Cooperation of cancer drivers with regulatory germline variants shapes clinical outcomes.
Authors: Musa Et al.
Nat Commun 2019;10:4128
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