Chemical Name: 2-[[[2-(Tetradecyl)phenyl]amino]carbonyl]benzoic acid
Biological ActivityCompetitive PTP1B inhibitor (IC50 = 0.781 μM). Binds catalytic P-loop of enzyme. Improves insulin sensitivity in obese mice in the glucose tolerance test and the homeostasis model assessment of insulin resistance index (HOMA-IR). Enhances insulin-induced glucose uptake in adipocytes and myotubes in vitro. Exhibits some selectivity for PTP1B over other protein tyrosine phosphatases, except TCPTP.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
A novel protein tyrosine phosphatase 1B inhibitor with therapeutic potential for insulin resistance.
Zhang et al.
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for CX08005
There are currently no reviews for this product. Be the first to review CX08005 and earn rewards!
Have you used CX08005?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image