Chemical Name:2-[[[2-(Tetradecyl)phenyl]amino]carbonyl]benzoic acid
Biological Activity Competitive PTP1B inhibitor (IC50 = 0.781 μM). Binds catalytic P-loop of enzyme. Improves insulin sensitivity in obese mice in the glucose tolerance test and the homeostasis model assessment of insulin resistance index (HOMA-IR). Enhances insulin-induced glucose uptake in adipocytes and myotubes in vitro. Exhibits some selectivity for PTP1B over other protein tyrosine phosphatases, except TCPTP.
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Store at +4°C
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