Recombinant Human Cyclin D2 His Protein

Name: Recombinant Human Cyclin D2 His Protein
Brand: Novus Biologicals
SKU: NBP1-78841
Price: 999 USD
Availability: InStock

Novus Biologicals | Catalog # NBP1-78841

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Product Specifications
Scientific Data
Preparation & Storage
Background
Product Documents
Specific Notices
Research Areas

Key Product Details

Source

E. coli

Tag

His

Applications

SDS-PAGE

View all Cyclin D2 Proteins and Enzymes »

Product Specifications

Description

A denatured recombinant protein with a N-Terminal His-tag and corresponding to the amino acids 1-289 of Human Cyclin D2

Source: E.coli

Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MGSHMELLCH EVDPVRRAVR DRNLLRDDRV LQNLLTIEER YLPQCSYFKC VQKDIQPYMR RMVATWMLEV CEEQKCEEEV FPLAMNYLDR FLAGVPTPKS HLQLLGAVCM FLASKLKETS PLTAEKLCIY TDNSIKPQEL LEWELVVLGK LKWNLAAVTP HDFIEHILRK LPQQREKLSL IRKHAQTFIA LCATDFKFAM YPPSMIATGS VGAAICGLQQ DEEVSSLTCD ALTELLAKIT NTDVDCLKAC QEQIEAVLLN SLQQYRQDQR DGSKSEDELD QASTPTDVRD IDL

Purity

>85%, by SDS-PAGE

Predicted Molecular Mass

35.6 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Protein / Peptide Type

Recombinant Protein

Scientific Data Images for Recombinant Human Cyclin D2 His Protein

SDS-PAGE: Recombinant Human Cyclin D2 His Protein [NBP1-78841]

SDS-Page: Recombinant Human Cyclin D2 Protein [NBP1-78841] - 15% SDS-PAGE (3ug)

Formulation, Preparation, and Storage

NBP1-78841

Formulation	20 mM Tris-HCl buffer (pH 8.0), 10% glycerol, 2 mM DTT, 1 M UREA.
Preservative	No Preservative
Concentration	1 mg/ml
Shipping	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage	Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Cyclin D2

CCND2 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. High level expression of this protein was observed in ovarian and testicular tumors. Recombinant human CCND2 protein, fused to His-tag at N-terminus, was expressed in E.coli.

Alternate Names

CCND2, Vin1

Gene Symbol

CCND2

Additional Cyclin D2 Products

Product Documents for Recombinant Human Cyclin D2 His Protein

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Certificate of Analysis

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Product Specific Notices for Recombinant Human Cyclin D2 His Protein

This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 1 year from date of receipt.

Related Research Areas

Cancer Biomarkers

Cell Cycle

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