Biological ActivityCyclotraxin B is an antagonist of TrkB receptors; inhibits BDNF-induced TrkB activity (IC50 = 0.30 nM). Allosterically alters TrkB receptor conformation but does not alter BDNF binding. Prevents BDNF-induced cold allodynia in mice. Also shown to exhibit putative anxiolytic properties in mice.
(Modifications: Disulfide bridge between 1 - 11)
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Cyclotraxin-B, a new TrkB antagonist, and glial blockade by propentofylline, equally prevent and reverse cold allodynia induced by BDNF or partial infraorbital nerve constriction in mice.
Constandil et al.
Cyclotraxin-B, the first highly potent and selective TrkB antagonist, has anxiolytic properties in mice.
Cazorla et al.
PLoS One, 2010;5:e9777
Citations for Cyclotraxin B
The citations listed below are publications that use Tocris products. Selected citations for Cyclotraxin B include:
2 Citations: Showing 1 - 2
Opposing Effects of CREBBP Mutations Govern the Phenotype of Rubinstein-Taybi Syndrome and Adult SHH Medulloblastoma.
Authors: Merk Et al.
Dev Cell 2018;44:709
BDNF interacts with endocannabinoids to regulate cocaine-induced synaptic plasticity in mouse midbrain DA neurons.
Authors: Zhong Et al.
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