Cyclotraxin B

Tocris Bioscience | Catalog # 5062

TrkB receptor antagonist
Tocris Bioscience

Key Product Details

Description

TrkB receptor antagonist
View all Trk Receptor Antagonists »

Product Description

Cyclotraxin B is an antagonist of TrkB receptors; inhibits BDNF-induced TrkB activity (IC50 = 0.30 nM). Allosterically alters TrkB receptor conformation but does not alter BDNF binding. Prevents BDNF-induced cold allodynia in mice. Also shown to exhibit putative anxiolytic properties in mice.

Product Specifications for Cyclotraxin B

Molecular Weight

1200.36

Formula

C48H73N13O17S3

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

1203586-72-4

PubChem ID

90489002

InChI Key

JLBMMJHZUYBFGX-ZHTCEXBHSA-N

SMILES

[H]N[C@H]1CSSC[C@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(N)=O)NC1=O)[C@@H](C)O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solubility Soluble to 2mg/ml in water

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 17 publications citing the usage of this product.

Product Documents for Cyclotraxin B

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Cyclotraxin B

For research use only

Related Research Areas

Receptor Tyrosine Kinases (RTKs)

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