Catalog Number: 5062
Biological Activity
Antagonist of TrkB receptors; inhibits BDNF-induced TrkB activity (IC50 = 0.30 nM). Allosterically alters TrkB receptor conformation but does not alter BDNF binding. Prevents BDNF-induced cold allodynia in mice. Also shown to exhibit putative anxiolytic properties in mice.
Technical Data
  • M.Wt:
    1200.36
  • Formula:
    C48H73N13O17S3
  • Sequence:
    CNPMGYTKEGC

    (Modifications: Disulfide bridge between 1 - 11)

  • Solubility:
    Soluble to 2 mg/ml in water
  • Storage:
    Store at -20°C
  • CAS No:
    1203586-72-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Cyclotraxin-B, a new TrkB antagonist, and glial blockade by propentofylline, equally prevent and reverse cold allodynia induced by BDNF or partial infraorbital nerve constriction in mice.
    Constandil et al.
    J.Pain, 2012;13:579
  2. Cyclotraxin-B, the first highly potent and selective TrkB antagonist, has anxiolytic properties in mice.
    Cazorla et al.
    PLoS One, 2010;5:e9777
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Cyclotraxin B include:

1 Citations: Showing 1 - 1

  1. BDNF interacts with endocannabinoids to regulate cocaine-induced synaptic plasticity in mouse midbrain dopamine neurons.
    Authors: Zhong Et al.
    Oncotarget 2015;35:4469

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