Catalog Number: 1843
Biological Activity
Potent and selective somatostatin sst2 receptor antagonist. pIC50 values are 8.58, 5.41, 6.07, 5.76 and 6.48 for human recombinant sst2, sst1, sst3, sst4 and sst5 receptors respectively.
Technical Data
  • M.Wt:
    1197.35
  • Formula:
    C56H68N12O14S2
  • Sequence:
    FCYWKTCY

    (Modifications: Phe-1 = Ac-(4-nitro)Phe, Cys-2 = D-Cys, Trp-4 = D-Trp, Tyr-8 = D-Tyr & C-terminal amide, Disulfide bridge between 2 - 7)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    183658-72-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Identification and characterization of novel somatostatin antagonists.
    Bass et al.
    Mol.Pharmacol., 1996;50:709
  2. Selective somatostatin sst2 receptor blockade with the novel cyclic octapeptide, CYN-154806.
    Feniuk et al.
    Neuropharmacology, 2000;39:1443
  3. Drug design at peptide receptors. Somatostatin receptor ligands.
    Hannon et al.
    J.Mol.Neurosci., 2002;18:15
Citations:

The citations listed below are publications that use Tocris products. Selected citations for CYN 154806 include:

4 Citations: Showing 1 - 4
Filter your results:

  1. Somatostatin and insulin mediate glucose-inhibited glucagon secretion in the pancreatic α-cell by lowering cAMP.
    Authors: Elliott Et al.
    Am J Physiol Endocrinol Metab 2015;308:E130
  2. Neurochemical characterisation of lamina II inhibitory interneurons that express GFP in the PrP-GFP mouse.
    Authors: Iwagaki Et al.
    Mol Pain 2013;9:56
  3. Analog of somatostatin vapreotide exhibits biological effects in vitro via interaction with neurokinin-1 receptor.
    Authors: Spitsin Et al.
    J Leukoc Biol 2013;20:247
  4. 5-HT(1A), SST(1), and SST(2) receptors mediate inhibitory postsynaptic potentials in the submucous plexus of the guinea pig ileum.
    Authors: Foong Et al.
    Neuroimmunomodulation 2010;298:G384

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