Biological ActivityCYN 154806 is a potent and selective somatostatin sst2 receptor antagonist. pIC50 values are 8.58, 5.41, 6.07, 5.76 and 6.48 for human recombinant sst2, sst1, sst3, sst4 and sst5 receptors respectively.
(Modifications: Phe-1 = Ac-(4-nitro)Phe, Cys-2 = D-Cys, Trp-4 = D-Trp, Tyr-8 = D-Tyr & C-terminal amide, Disulfide bridge: 2-7)
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Identification and characterization of novel somatostatin antagonists.
Bass et al.
Selective somatostatin sst2 receptor blockade with the novel cyclic octapeptide, CYN-154806.
Feniuk et al.
Drug design at peptide receptors. Somatostatin receptor ligands.
Hannon et al.
Citations for CYN 154806
The citations listed below are publications that use Tocris products. Selected citations for CYN 154806 include:
8 Citations: Showing 1 - 8
Somatostatin 2 Receptors in the Spinal Cord Tonically Restrain Thermogenic, Cardiac and Other Sympathetic Outflows.
Authors: Bowman Et al.
Front Neurosci 2019;13:121
Electrophysiological properties of human beta-cell lines EndoC-βH1 and -βH2 conform with human beta-cells.
Authors: Hastoy Et al.
Sci Rep 2018;8:16994
Targeting Somatostatin Receptors By Functionalized Mesoporous Silica Nanoparticles - Are We Striking Home?.
Authors: Paramonov Et al.
Somatostatin and Ins mediate glucose-inhibited glucagon secretion in the pancreatic α-cell by lowering cAMP.
Authors: Elliott Et al.
Am J Physiol Endocrinol Metab 2015;308:E130
Neurochemical characterisation of lamina II inhibitory interneurons that express GFP in the PrP-GFP mouse.
Authors: Iwagaki Et al.
Mol Pain 2013;9:56
Analog of somatostatin vapreotide exhibits biological effects in vitro via interaction with neurokinin-1 receptor.
Authors: Spitsin Et al.
J Leukoc Biol 2013;20:247
5-HT(1A), SST(1), and SST(2) receptors mediate inhibitory postsynaptic potentials in the submucous plexus of the guinea pig ileum.
Authors: Foong Et al.
Activation of submucosal 5-HT(3) receptors elicits a somatostatin-dependent inhibition of ion secretion in rat colon.
Authors: Yang Et al.
Br J Pharmacol 2010;159:1623
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