antagonist, migraine prophylactic. Also SETD7/9 inhibitor (IC50
M). Decreases expression and increases degradation of estrogen receptor (ER) α
in breast tumor MCF7 cells. Inhibits growth of MCF7 xenografts in mice.
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All Tocris products are intended for laboratory research use only.
Inhibitory 5-hydroxytryptamine receptors involved in pressor effects obtained by stimulation of sympathetic outflow from spinal cord in pithed rats.
Moran et al.
VII. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin).
Hoyer et al.
Identification of cyproheptadine as an inhibitor of SET domain containing lysine methyltransferase 7/9 (Set7/9) that regulates estrogen-dependent transcription.
Takemoto et al.
The citations listed below are publications that use Tocris products. Selected citations for Cyproheptadine hydrochloride include:
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