Catalog Number: 0996
Chemical Name: 4-(5H-Dibenzo[a,d]cyclohepten-5-ylidine)-methylpiperidine hydrochloride
Biological Activity
Non-selective 5HT2 antagonist, migraine prophylactic. Also SETD7/9 inhibitor (IC50 = 1μM). Decreases expression and increases degradation of estrogen receptor (ER) α in breast tumor MCF7 cells. Inhibits growth of MCF7 xenografts in mice.
Technical Data
  • M.Wt:
    323.86
  • Formula:
    C21H21N.HCl
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    969-33-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Inhibitory 5-hydroxytryptamine receptors involved in pressor effects obtained by stimulation of sympathetic outflow from spinal cord in pithed rats.
    Moran et al.
    Br.J.Pharmacol., 1994;113:1358
  2. VII. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin).
    Hoyer et al.
    Pharmacol.Rev., 1994;46:157
  3. Identification of cyproheptadine as an inhibitor of SET domain containing lysine methyltransferase 7/9 (Set7/9) that regulates estrogen-dependent transcription.
    Takemoto et al.
    J.Med.Chem., 2016;59:3650
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Cyproheptadine hydrochloride include:

2 Citations: Showing 1 - 2
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  1. Recovery of motoneuron and locomotor function after spinal cord injury depends on constitutive activity in 5-HT2C receptors.
    Authors: Murray Et al.
    Nat Med 2010;16:694
  2. Locomotion after spinal cord injury depends on constitutive activity in serotonin receptors.
    Authors: Fouad Et al.
    J Neurophysiol 2010;104:2975

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