Cysmethynil

Catalog # Availability Size / Price Qty
7337/10

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Cysmethynil | CAS No. 851636-83-4 | Other Transferase Inhibitors
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Description: ICMT inhibitor; arrests cell-cycle at G1 phase

Chemical Name: 5-(3-Methylphenyl)-1-octyl-1H-indole-3-acetamide

Purity: ≥98%

Product Details
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Biological Activity

Cysmethynil is an isoprenylcysteine carboxylmethyltransferase (ICMT) inhibitor (IC50 = 2.4 μM). Cysmethynil reduces growth of RAS-mutant cell lines in vitro and in vivo (EC50 = 20 μM) and reduces cell viability in a variety of cell lines (IC50 = 16.8-23.3 μM). Tumor growth, mTOR signaling and cell proliferation are inhibited by cysmethynil; apoptosis is induced. Cysmethynil increases p27 and p21 proteins and arrests cell-cycle at the G1 phase.

Technical Data

M.Wt:
376.54
Formula:
C25H32N2O
Solubility:
Soluble to 100 mM in ethanol and to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
851636-83-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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