Cytosporone B

Key Product Details

Product Description

Cytosporone B is a naturally occurring Nur77 (NR4A1) agonist (K_d = 8.52 x 10^-7 M). Induces apoptosis in gastric cancer cells in vitro. Increases blood glucose levels in fasting C57 mice and suppresses xenograft tumor growth. Also exhibits a potent antifibrotic effect in bleomycin-induced skin fibrosis in vivo.

Product Specifications for Cytosporone B

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Cytosporone B

The following data is based on the product molecular weight 322.40.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.10 mL	15.51 mL	31.02 mL
5 mM	0.62 mL	3.10 mL	6.20 mL
10 mM	0.31 mL	1.55 mL	3.10 mL
50 mM	0.06 mL	0.31 mL	0.62 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

• Zhan Cytosporone B is an agonist for nuclear orphan receptor Nur77. Nat.Chem.Biol. 2008 PMID: 18690216
• Palumbo-Zerr Orphan nuclear receptor NR4A1 regulates transforming growth factor-β signaling and fibrosis. Nat.Med. 2015 PMID: 25581517

Product Documents for Cytosporone B