Catalog Number: 5459
Chemical Name: Ethyl 3,5-dihydroxy-2-(1-oxooctyl)-benzeneacetate
Biological Activity
Naturally occurring Nur77 (NR4A1) agonist (Kd = 8.52 x 10-7 M). Induces apoptosis in gastric cancer cells in vitro. Increases blood glucose levels in fasting C57 mice and suppresses xenograft tumor growth. Also exhibits a potent antifibrotic effect in bleomycin-induced skin fibrosis in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Orphan nuclear receptor NR4A1 regulates transforming growth factor-β signaling and fibrosis.
    Palumbo-Zerr et al.
    Nat.Med., 2015;21:150
  2. Cytosporone B is an agonist for nuclear orphan receptor Nur77.
    Zhan et al.
    Nat.Chem.Biol., 2008;4:548
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