Naturally occurring Nur77 (NR4A1) agonist (Kd
= 8.52 x 10-7
M). Induces apoptosis in gastric cancer cells in vitro
. Increases blood glucose levels in fasting C57 mice and suppresses xenograft tumor growth. Also exhibits a potent antifibrotic effect in bleomycin-induced skin fibrosis in vivo
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Orphan nuclear receptor NR4A1 regulates transforming growth factor-β signaling and fibrosis.
Palumbo-Zerr et al.
Cytosporone B is an agonist for nuclear orphan receptor Nur77.
Zhan et al.