CZC 25146

Catalog # Availability Size / Price Qty
6071/50
6071/10
CZC 25146 | CAS No. 1191911-26-8 | LRRK2 Inhibitors
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Description: Potent LRRK2 inhibitor

Chemical Name: N-[2-[[5-Fluoro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]methanesulfonamide

Purity: ≥98%

Product Details
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Biological Activity

CZC 25146 is a potent LRRK2 inhibitor (IC50 values are 4.76 and 6.87 nM for for wild-type and G2019S mutant forms of LRRK2, respectively). Also inhibits PLK4, GAK, TNK1, CAMKK2 and PIP4K2. Attenuates mutant LRRK2-induced injury of cultured rodent and human neurons. Cell permeable.

Technical Data

M.Wt:
488.54
Formula:
C22H25FN6O4S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1191911-26-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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