CZC 54252 hydrochloride

Key Product Details

Product Description

CZC 54252 hydrochloride is a potent inhibitor of leucine-rich repeat kinase 2 (LRRK2) (IC₅₀ values are 1.28 nM and 1.85 nM for wild-type and G2019S mutant forms of LRRK2 respectively). Attenuates neuronal injury induced by LRRK2-G2019S mutant activity in primary human neurons (EC₅₀ = 1 nM).

Product Specifications for CZC 54252 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for CZC 54252 hydrochloride

The following data is based on the product molecular weight 541.45.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.85 mL	9.23 mL	18.47 mL
5 mM	0.37 mL	1.85 mL	3.69 mL
10 mM	0.18 mL	0.92 mL	1.85 mL
50 mM	0.04 mL	0.18 mL	0.37 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Kramer Small molecule kinase inhibitors for LRRK2 and their application to Parkinson's disease models. ACS Chem.Neurosci. 2012 PMID: 22860184
• Ramsden Chemoproteomics-based design of potent LRRK2-selective lead compounds that attenuate Parkinson's disease-related toxicity in human neurons. ACS Chem.Biol. 2011 PMID: 21812418

Product Documents for CZC 54252 hydrochloride