CZC 54252 hydrochloride

Catalog # Availability Size / Price Qty
4534/10
4534/50
Cat.No. 4534 - CZC 54252 hydrochloride | C22H25ClN6O4S.HCl | CAS No. 1191911-27-9
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Description: Potent LRRK2 inhibitor; neuroprotective

Chemical Name: N-[2-[[5-Chloro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]methanesulfonamide hydrochloride

Product Details
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Biological Activity

Potent inhibitor of leucine-rich repeat kinase 2 (LRRK2) (IC50 values are 1.28 nM and 1.85 nM for wild-type and G2019S mutant forms of LRRK2 respectively). Attenuates neuronal injury induced by LRRK2-G2019S mutant activity in primary human neurons (EC50 = 1 nM).

Technical Data

Formula:
C22H25ClN6O4S.HCl
Solubility:
Soluble to 100 mM in DMSO
Storage:
Store the unopened product at 2 - 8 °C. Do not use past expiration date.
CAS No:
1191911-27-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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