CZC 54252 hydrochloride
Chemical Name: N-[2-[[5-Chloro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]methanesulfonamide hydrochloride
Biological ActivityCZC 54252 hydrochloride is a potent inhibitor of leucine-rich repeat kinase 2 (LRRK2) (IC50 values are 1.28 nM and 1.85 nM for wild-type and G2019S mutant forms of LRRK2 respectively). Attenuates neuronal injury induced by LRRK2-G2019S mutant activity in primary human neurons (EC50 = 1 nM).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Chemoproteomics-based design of potent LRRK2-selective lead compounds that attenuate Parkinson's disease-related toxicity in human neurons.
Ramsden et al.
ACS Chem.Biol., 2011;6:1021
Small molecule kinase inhibitors for LRRK2 and their application to Parkinson's disease models.
Kramer et al.
ACS Chem.Neurosci., 2012;3:151
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for CZC 54252 hydrochloride
There are currently no reviews for this product. Be the first to review CZC 54252 hydrochloride and earn rewards!
Have you used CZC 54252 hydrochloride?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image