CZC 54252 hydrochloride

Catalog # Availability Size / Price Qty
4534/10
4534/50
LRRK2 Inhibitors Small Molecule
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Description: Potent LRRK2 inhibitor; neuroprotective

Chemical Name: N-[2-[[5-Chloro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]methanesulfonamide hydrochloride

Purity: ≥98%

Product Details
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Biological Activity

Potent inhibitor of leucine-rich repeat kinase 2 (LRRK2) (IC50 values are 1.28 nM and 1.85 nM for wild-type and G2019S mutant forms of LRRK2 respectively). Attenuates neuronal injury induced by LRRK2-G2019S mutant activity in primary human neurons (EC50 = 1 nM).

Technical Data

M.Wt:
541.45
Formula:
C22H25ClN6O4S.HCl
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1191911-27-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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