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[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P

  ( 3 citations )    
Product Datasheet
Catalog Number:1946
Chemical Name:
Product Details
Citations (3)
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Reviews
Biological Activity
Broad spectrum neuropeptide inverse agonist and antagonist. Potent full inverse agonist for the ghrelin receptor (EC50 = 5.2 nM); diminishes constitutive ghrelin receptor signaling. Also antagonist at tachykinin, bradykinin, CCK and bombesin receptors. Induces apoptosis and inhibits cancer cell growth in vitro.
Technical Data
  • M.Wt:
    1516.85
  • Formula:
    C79H109N19O12
  • Sequence:
    RPKPFQWFWLL

    (Modifications: Arg-1 = D-Arg, Phe-5 = D-Phe, Trp-7 = Trp-9 = D-Trp, Leu-11 = C-terminal amide)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    96736-12-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P include:

3 Citations: Showing 1 - 3
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  1. A novel non-peptidic agonist of the ghrelin receptor with orexigenic activity In vivo
    Authors: Pastor-Cavada Et al.
    Scientific Reports  2016;6:36456
  2. Devil's Claw to suppress appetite--ghrelin receptor modulation potential of a Harpagophytum procumbens root extract.
    Authors: Torres-Fuentes Et al.
    Oncotarget  2014;9:e103118
  3. Promiscuous dimerization of the growth hormone secretagogue receptor (GHS-R1a) attenuates ghrelin-mediated signaling.
    Authors: Schellekens Et al.
    J Biol Chem  2013;288:181

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