Home / Ghrelin Receptor Inverse Agonists / [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P

[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P

1946 3 Citations Datasheet / COA / SDS

Discontinued Product

1946 has been discontinued.
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[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P
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Description: Potent ghrelin receptor inverse agonist; Antagonist at other neuropeptide receptors
Product Details
Citations (3)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P is a broad spectrum neuropeptide inverse agonist and antagonist. Potent full inverse agonist for the ghrelin receptor (EC50 = 5.2 nM); diminishes constitutive ghrelin receptor signaling. Also antagonist at tachykinin, bradykinin, CCK and bombesin receptors. Induces apoptosis and inhibits cancer cell growth in vitro.

Technical Data

M.Wt:
1516.85
Formula:
C79H109N19O12
Sequence:
RPKPFQWFWLL

(Modifications: Arg-1 = D-Arg, Phe-5 = D-Phe, Trp-7 = Trp-9 = D-Trp, Leu-11 = C-terminal amide)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
96736-12-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P

The citations listed below are publications that use Tocris products. Selected citations for [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P include:

3 Citations: Showing 1 - 3

  1. A novel non-peptidic agonist of the ghrelin receptor with orexigenic activity In vivo
    Authors: Pastor-Cavada Et al.
    Scientific Reports  2016;6:36456
  2. Devil's Claw to suppress appetite--ghrelin receptor modulation potential of a Harpagophytum procumbens root extract.
    Authors: Torres-Fuentes Et al.
    Oncotarget  2014;9:e103118
  3. Promiscuous dimerization of the GH secretagogue receptor (GHS-R1a) attenuates ghrelin-mediated signaling.
    Authors: Schellekens Et al.
    J Biol Chem  2013;288:181

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