[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P

Catalog # Availability Size / Price Qty
1946/1
[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P
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Description: Potent ghrelin receptor inverse agonist; Antagonist at other neuropeptide receptors
Product Details
Citations (3)
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Biological Activity

Broad spectrum neuropeptide inverse agonist and antagonist. Potent full inverse agonist for the ghrelin receptor (EC50 = 5.2 nM); diminishes constitutive ghrelin receptor signaling. Also antagonist at tachykinin, bradykinin, CCK and bombesin receptors. Induces apoptosis and inhibits cancer cell growth in vitro.

Technical Data

M.Wt:
1516.85
Formula:
C79H109N19O12
Sequence:
RPKPFQWFWLL

(Modifications: Arg-1 = D-Arg, Phe-5 = D-Phe, Trp-7 = Trp-9 = D-Trp, Leu-11 = C-terminal amide)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
96736-12-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P

The citations listed below are publications that use Tocris products. Selected citations for [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P include:

3 Citations: Showing 1 - 3

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