Biological ActivityBroad spectrum neuropeptide inverse agonist and antagonist. Potent full inverse agonist for the ghrelin receptor (EC50 = 5.2 nM); diminishes constitutive ghrelin receptor signaling. Also antagonist at tachykinin, bradykinin, CCK and bombesin receptors. Induces apoptosis and inhibits cancer cell growth in vitro.
(Modifications: Arg-1 = D-Arg, Phe-5 = D-Phe, Trp-7 = Trp-9 = D-Trp, Leu-11 = C-terminal amide)
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Tocris products are intended for laboratory research use only, unless stated otherwise.
High constitutive signaling of the ghrelin receptor - identification of a potent inverse agonist.
Holst et al.
[D-Arg1, D-Phe5, D-Trp7,9, Leu11] Substance P acts as a biased agonist toward neuropeptide and chemokine receptors.
Jarpe et al.
[D-Arg1, D-Phe5, D-Trp7,9, Leu11] Substance P induces apoptosis in lung cancer cells in vitro.
Reeve and Bleehen
Citations for [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P
The citations listed below are publications that use Tocris products. Selected citations for [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P include:
3 Citations: Showing 1 - 3
A novel non-peptidic agonist of the ghrelin receptor with orexigenic activity In vivo
Authors: Pastor-Cavada Et al.
Scientific Reports 2016;6:36456
Devil's Claw to suppress appetite--ghrelin receptor modulation potential of a Harpagophytum procumbens root extract.
Authors: Torres-Fuentes Et al.
Promiscuous dimerization of the GH secretagogue receptor (GHS-R1a) attenuates ghrelin-mediated signaling.
Authors: Schellekens Et al.
J Biol Chem 2013;288:181
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