[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P

Tocris Bioscience | Catalog # 1946

Potent ghrelin receptor inverse agonist; Antagonist at other neuropeptide receptors
Tocris Bioscience
Discontinued Product
1946 has been discontinued. View all Ghrelin Receptor Inverse Agonists products.

Key Product Details

Description

Potent ghrelin receptor inverse agonist; Antagonist at other neuropeptide receptors
View all Ghrelin Receptor Inverse Agonists »

Product Description

[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P is a broad spectrum neuropeptide inverse agonist and antagonist. Potent full inverse agonist for the ghrelin receptor (EC50 = 5.2 nM); diminishes constitutive ghrelin receptor signaling. Also antagonist at tachykinin, bradykinin, CCK and bombesin receptors. Induces apoptosis and inhibits cancer cell growth in vitro.

Product Specifications

Molecular Weight

1516.85

Formula

C79H109N19O12

Storage

Desiccate at -20°C

CAS Number

96736-12-8

PubChem ID

25091011

InChI Key

XVOCEQLNJQGCQG-ACRSGXKRSA-N

SMILES

[H]N[C@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solubility Soluble to 1mg/ml in water

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 27 publications citing the usage of this product.

Product Documents

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices

For research use only

Citations for [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P

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