d[Leu⁴,Lys⁸]-VP

Name: d[Leu 4 ,Lys 8 ]-VP
Brand: Tocris Bioscience
SKU: 3127

Tocris Bioscience | Catalog # 3127

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Citations (25)

Product Documents

Selective V1B agonist

Discontinued Product

3127 has been discontinued. View all Vasopressin Receptor Agonists products.

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Selective V1B agonist

View all Vasopressin Receptor Agonists »

Product Description

d[Leu⁴,Lys⁸]-VP is a selective vasopressin V_1B receptor agonist (K_i values are 0.16, 64, 100 and 3800 nM for V_1B, oxytocin, V₂ and V_1A receptors respectively). Displays weak antidiuretic, vasopressor and in vitro oxytocic activities.

Product Specifications for d[Leu⁴,Lys⁸]-VP

Molecular Weight

1026.20

Formula

C₄₇H₆₇N₁₁O₁₁S₂

Storage

Store at -20°C

CAS Number

42061-33-6

PubChem ID

44419030

InChI Key

QGZMLGLFLYCDQT-PEAOEFARSA-N

SMILES

CC(C)C[C@@H]1NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)CCSSC[C@H](NC(=O)[C@H](CC(N)=O)NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)NCC(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 2mg/ml in water

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 25 publications citing the usage of this product.

Pena Pharmacological and physiological characterization of d[Leu⁴,Lys⁸]vasopressin, the first V_1b-selective agonist for rat vasopressin/oxytocin receptors. Endocrinology 2007 PMID: 17495006
Pena Design and synthesis of the frist selective agonists for the rat vasopressin V_1b receptor: based on modifications of deamino-[cys¹]arginine vasopressin at positions 4 and 8. J.Med.Chem. 2007 PMID: 17300166

Product Documents for d[Leu⁴,Lys⁸]-VP

Certificate of Analysis

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Product Specific Notices for d[Leu⁴,Lys⁸]-VP

For research use only

Citations for d[Leu⁴,Lys⁸]-VP

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