Biological ActivitySelective vasopressin V1B receptor agonist (Ki values are 0.16, 64, 100 and 3800 nM for V1B, oxytocin, V2 and V1A receptors respectively). Displays weak antidiuretic, vasopressor and in vitro oxytocic activities.
(Modifications: X = Mpr, Gly-9 = C-terminal amide, Disulfide bridge between X-1 - Cys-6)
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Design and synthesis of the frist selective agonists for the rat vasopressin V1b receptor: based on modifications of deamino-[cys1]arginine vasopressin at positions 4 and 8.
Pena et al.
Pharmacological and physiological characterization of d[Leu4,Lys8]vasopressin, the first V1b-selective agonist for rat vasopressin/oxytocin receptors.
Pena et al.
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