Catalog Number: 0226
Biological Activity

Glycine agonist at the NMDA receptor.

L-isomer also available.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. D-Serine as a neuromodulator: regional and developmental localizations in rat brain glia resemble NMDA receptors.
    Schell et al.
    J. Neurosci., 1997;17:1604
  2. Non-competitive NMDA antagonists.
    The NMDA Receptor (2nd edition). Eds. G.L.Collingr, 1989;:37
  3. D-serine is an endogenous ligand for the glycine site of the N-methyl-D-aspartate receptor.
    Mothet et al.
    Proc.Natl.Acad.Sci.USA, 2000;97:4926

The citations listed below are publications that use Tocris products. Selected citations for D-Serine include:

6 Citations: Showing 1 - 6
Filter your results:

  1. Optical control of NMDA receptors with a diffusible photoswitch.
    Authors: Laprell Et al.
    Proc Natl Acad Sci U S A 2015;6:8076
  2. Muscarinic regulation of dopamine and glutamate transmission in the nucleus accumbens.
    Authors: Shin Et al.
    J Neurosci 2015;112:8124
  3. Lovastatin modulates glycogen synthase kinase-3β pathway and inhibits mossy fiber sprouting after pilocarpine-induced status epilepticus.
    Authors: Lee Et al.
    J Biol Chem 2012;7:e38789
  4. Contribution of the d-Serine-Dependent Pathway to the Cellular Mechanisms Underlying Cognitive Aging.
    Authors: Potier Et al.
    Front Aging Neurosci 2010;2:1
  5. NMDA- and β-amyloid1-42-induced neurotoxicity is attenuated in serine racemase knock-out mice.
    Authors: Inoue Et al.
    PLoS One 2008;28:14486
  6. Subpallial origin of a population of projecting pioneer neurons during corticogenesis.
    Authors: Morante-Oria Et al.
    Proc Natl Acad Sci U S A 2003;100:12468

Have you used D-Serine?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details


Contact Information


Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

or select another batch: 


Customer Information