Biological ActivitySubstance P analog that inhibits activation of Gq/11 by M1 muscarinic ACh receptors. Does not inhibit Gi/o activation by M2 ACh receptors.
(Modifications: Trp-7, Trp-9, Trp-10 = D-Trp, Met-11 = C-terminal Amide)
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
G protein antagonists. A novel hydrophobic peptide competes with receptor for G protein binding.
Mukai et al.
Citation for [D-Trp7,9,10]-Substance P
The citations listed below are publications that use Tocris products. Selected citations for [D-Trp7,9,10]-Substance P include:
1 Citation: Showing 1 - 1
Microtubule dynamics at the growth cone are mediated by α7 nicotinic receptor activation of a Gαq and IP3 receptor pathway.
Authors: Nordman and Kabbani
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VersaClone cDNA Plasmids
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