[D-Trp7,9,10]-Substance P
Discontinued Product
![[D-Trp7,9,10]-Substance P](https://resources.rndsystems.com/images/datasheets/structures/d-trp-7-9-10-substance-p_1884.png "[D-Trp7,9,10]-Substance P")
Biological Activity
[D-Trp7,9,10]-Substance P is a substance P analog that inhibits activation of Gq/11 by M1 muscarinic ACh receptors. Does not inhibit Gi/o activation by M2 ACh receptors.Technical Data
(Modifications: Trp-7, Trp-9, Trp-10 = D-Trp, Met-11 = C-terminal Amide)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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G protein antagonists. A novel hydrophobic peptide competes with receptor for G protein binding.
Mukai et al.
J.Biol.Chem., 1992;267:16237
Product Datasheets
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Citation for [D-Trp7,9,10]-Substance P
The citations listed below are publications that use Tocris products. Selected citations for [D-Trp7,9,10]-Substance P include:
1 Citation: Showing 1 - 1
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Microtubule dynamics at the growth cone are mediated by α7 nicotinic receptor activation of a Gαq and IP3 receptor pathway.
Authors: Nordman and Kabbani
Diabetes 2014;28:2995
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