Catalog Number: 3790
Alternate Names: [D-Ala2, D-Leu5]-Enkephalin
Biological Activity
Prototypical δ-opioid receptor agonist that also displays activity at the μ-opioid receptor. Displays antinociceptive activity in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Sequence:

    (Modifications: Ala-2 = D-Ala, Leu-5 = D-Leu)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Pharmacological profile of various κ-agonists at κ-, μ- and δ-opioid receptors mediating presynaptic inhibition of neurotransmitter release in the rat brain.
    Mulder et al.
    Br.J.Pharmacol., 1991;102:518
  2. Delta opioid agonist [D-Ala2, D-Leu5] enkephalin (DADLE) reduced oxygen-glucose deprivation caused neuronal injury through the MAPK pathway.
    Ke et al.
    Brain Res., 2009;1292:100
  3. Different types of opioid receptors mediating analgesia induced by morphine, DAMGO, DPDPE, DADLE and beta-endorphin in mice.
    Suh and Tseng
    Naunyn-Schmied.Arch.Pharmacol., 1990;342:67
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