-opioid receptor agonist that also displays activity at the μ
-opioid receptor. Displays antinociceptive activity in vivo
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Pharmacological profile of various κ-agonists at κ-, μ- and δ-opioid receptors mediating presynaptic inhibition of neurotransmitter release in the rat brain.
Mulder et al.
Delta opioid agonist [D-Ala2, D-Leu5] enkephalin (DADLE) reduced oxygen-glucose deprivation caused neuronal injury through the MAPK pathway.
Ke et al.
Brain Res., 2009;1292:100
Different types of opioid receptors mediating analgesia induced by morphine, DAMGO, DPDPE, DADLE and beta-endorphin in mice.
Suh and Tseng