Biological ActivityDADLE is a prototypical δ-opioid receptor agonist that also displays activity at the μ-opioid receptor. Displays antinociceptive activity in vivo.
(Modifications: Ala-2 = D-Ala, Leu-5 = D-Leu)
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Pharmacological profile of various κ-agonists at κ-, μ- and δ-opioid receptors mediating presynaptic inhibition of neurotransmitter release in the rat brain.
Mulder et al.
Delta opioid agonist [D-Ala2, D-Leu5] enkephalin (DADLE) reduced oxygen-glucose deprivation caused neuronal injury through the MAPK pathway.
Ke et al.
Brain Res., 2009;1292:100
Different types of opioid receptors mediating analgesia induced by morphine, DAMGO, DPDPE, DADLE and beta-endorphin in mice.
Suh and Tseng
Citation for DADLE
The citations listed below are publications that use Tocris products. Selected citations for DADLE include:
1 Citation: Showing 1 - 1
A PTEN-Regulated Checkpoint Controls Surface Delivery of δ Opioid Receptors.
Authors: Shiwarski Et al.
J Neurosci 2017;37:3741
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