Chemical Name: 3-(Methylsulfonyl)propanenitrile
Biological ActivityDapansutrile is a NLRP3 inflammasome inhibitor that disrupts inflammasome formation. Reduces LPS/ATP-induced IL-1β secretion in human and mouse macrophages in vitro, without affecting TNFα levels. Reduces LPS-induced inflammation in vivo. Also reduces joint swelling and markers of inflammation in synovial fluid in a mouse model of acute arthritis. Displays cardioprotective effects in a mouse model of cardiac ischemic reperfusion injury.
OLT1177® is a registered trademark of Olatec Therapeutics LLC in the United States and other countries.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
OLT1177®, a β-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation.
Marchetti et al.
NLRP3 inflammasome inhibitor OLT1177® suppresses joint inflammation in murine models of acute arthritis.
Marchetti et al.
Arthritis Res.Ther., 2018;20:169
The NLRP3 inflammasome inhibitor, OLT1177® (Dapansutrile), reduces infarct size and preserves contractile function after ischemia reperfusion injury in the mouse.
Toldo et al.
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