Catalog Number: 3917
Alternate Names: LY 146032
Chemical Name: N-(1-Oxodecyl)-L-tryptophyl-D-asparaginyl-L-α-aspartyl-L-threonylglycyl-L-ornithinyl-L-α-aspartyl-D-alanyl-L-α-aspartylglycyl-D-seryl-(3R)-3-methyl-L-α-glutamyl-α,2-diamino-γ-oxo-benzene butanoic acid (13-4) lactone
Biological Activity
Lipopeptide, calcium-dependent antibiotic. Exhibits potent bacteriocidal activity against most gram-positive bacteria in vitro and in vivo, including antibiotic-resistant strains such as MRSA and VRE. Disrupts plasma membrane function; activity results in membrane depolarization leading to inhibition of protein, DNA and RNA synthesis.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 20 mM in water
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Structural transitions as determinants of the action of the calcium-dependent antibiotic daptomycin.
    Jung et al.
    Chem.Biol., 2004;11:949
  2. Daptomycin: a lipopeptide antibiotic for the treatment of serious gram-positive infections.
    Steenbergen et al.
    J.Antimicrob Chemother., 2005;55:283
  3. Daptomycin, a bacterial lipopeptide synthesized by a non-ribosomal machinery.
    Robbel and Marahiel
    J.Biol.Chem., 2010;285:27501
  4. Development of daptomycin for gram-positive infections.
    Tally and DeBruin
    J.Antimicrob Chemother., 2000;46:523
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