Chemical Name: N-(1-Oxodecyl)-L-tryptophyl-D-asparaginyl-L-α-aspartyl-L-threonylglycyl-L-ornithinyl-L-α-aspartyl-D-alanyl-L-α-aspartylglycyl-D-seryl-(3R)-3-methyl-L-α-glutamyl-α,2-diamino-γ-oxo-benzene butanoic acid (13-4) lactone
Biological ActivityLipopeptide, calcium-dependent antibiotic. Exhibits potent bacteriocidal activity against most gram-positive bacteria in vitro and in vivo, including antibiotic-resistant strains such as MRSA and VRE. Disrupts plasma membrane function; activity results in membrane depolarization leading to inhibition of protein, DNA and RNA synthesis.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Daptomycin: a lipopeptide antibiotic for the treatment of serious gram-positive infections.
Steenbergen et al.
J.Antimicrob Chemother., 2005;55:283
Daptomycin, a bacterial lipopeptide synthesized by a non-ribosomal machinery.
Robbel and Marahiel
Development of dapto. for gram-positive infections.
Tally and DeBruin
J.Antimicrob Chemother., 2000;46:523
Structural transitions as determinants of the action of the calcium-dependent antibiotic dapto.
Jung et al.
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