Daptomycin

Tocris Bioscience | Catalog # 3917

Antibiotic; inhibits protein, DNA and RNA synthesis in gram-positive bacteria
Tocris Bioscience

Key Product Details

Description

Antibiotic; inhibits protein, DNA and RNA synthesis in gram-positive bacteria

Alternative Names

LY 146032
View all Antibiotics »

Product Description

Daptomycin is a lipopeptide, calcium-dependent antibiotic. Exhibits potent bacteriocidal activity against most gram-positive bacteria in vitro and in vivo, including antibiotic-resistant strains such as MRSA and VRE. Disrupts plasma membrane function; activity results in membrane depolarization leading to inhibition of protein, DNA and RNA synthesis.

Product Specifications for Daptomycin

Molecular Weight

1620.67

Formula

C72H101N17O26

Storage

Store at -20°C

Purity

≥95% (HPLC)

Chemical Name

N-(1-Oxodecyl)-L-tryptophyl-D-asparaginyl-L-α-aspartyl-L-threonylglycyl-L-ornithinyl-L-α-aspartyl-D-alanyl-L-α-aspartylglycyl-D-seryl-(3R)-3-methyl-L-α-glutamyl-α,2-diamino-γ-oxo-benzene butanoic acid (13-4) lactone

CAS Number

103060-53-3

PubChem ID

16129629

InChI Key

DOAKLVKFURWEDJ-OFNKPWESSA-N

SMILES

O=C(N[C@@H](CCCN)C(N[C@@H](CC(O)=O)C(N[C@H](C)C4=O)=O)=O)CN[C@]([C@H]([C@H](OC([C@@H](NC([C@@H](NC([C@@H](CO)NC(CNC([C@@H](N4)CC(O)=O)=O)=O)=O)[C@@H](C)CC(O)=O)=O)CC(C3=CC=CC=C3N)=O)=O)C)NC([C@H](CC(O)=O)NC([C@@H](CC(N)=O)NC([C@H](CC1=CNC2=C1C=CC=C2)NC(CCCCCCCCC)=O)=O)=O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 32.41 20
DMSO 162.07 100

Preparing Stock Solutions for Daptomycin

The following data is based on the product molecular weight 1620.67.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.62 mL 3.09 mL 6.17 mL
5 mM 0.12 mL 0.62 mL 1.23 mL
10 mM 0.06 mL 0.31 mL 0.62 mL
50 mM 0.01 mL 0.06 mL 0.12 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 13 publications citing the usage of this product.

Product Documents for Daptomycin

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Daptomycin

For research use only

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