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Daptomycin | CAS No. 103060-53-3 | Antibiotics
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Description: Antibiotic; inhibits protein, DNA and RNA synthesis in gram-positive bacteria
Alternative Names: LY 146032

Chemical Name: N-(1-Oxodecyl)-L-tryptophyl-D-asparaginyl-L-α-aspartyl-L-threonylglycyl-L-ornithinyl-L-α-aspartyl-D-alanyl-L-α-aspartylglycyl-D-seryl-(3R)-3-methyl-L-α-glutamyl-α,2-diamino-γ-oxo-benzene butanoic acid (13-4) lactone

Purity: ≥95%

Product Details

Biological Activity

Daptomycin is a lipopeptide, calcium-dependent antibiotic. Exhibits potent bacteriocidal activity against most gram-positive bacteria in vitro and in vivo, including antibiotic-resistant strains such as MRSA and VRE. Disrupts plasma membrane function; activity results in membrane depolarization leading to inhibition of protein, DNA and RNA synthesis.

Technical Data

Soluble to 100 mM in DMSO and to 20 mM in water
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Daptomycin: a lipopeptide antibiotic for the treatment of serious gram-positive infections.
    Steenbergen et al.
    J.Antimicrob Chemother., 2005;55:283
  2. Daptomycin, a bacterial lipopeptide synthesized by a non-ribosomal machinery.
    Robbel and Marahiel
    J.Biol.Chem., 2010;285:27501
  3. Development of dapto. for gram-positive infections.
    Tally and DeBruin
    J.Antimicrob Chemother., 2000;46:523
  4. Structural transitions as determinants of the action of the calcium-dependent antibiotic dapto.
    Jung et al.
    Chem.Biol., 2004;11:949

Product Datasheets

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