Darunavir

Tocris Bioscience | Catalog # 6710

Highly potent HIV protease inhibitor
Tocris Bioscience

Key Product Details

Description

Highly potent HIV protease inhibitor
View all HIV Protease Inhibitors »

Product Description

Darunavir is a highly potent HIV protease inhibitor (IC50 = 3 - 6 nM, depending on laboratory HIV-1 strain). Displays activity in cells infected with clinical HIV-1 strains shown to have resistance to other protease inhibitors.

Tocris products are for biomedical research use only. They are not intended for human or veterinary use.

Product Specifications for Darunavir

Molecular Weight

547.66

Formula

C27H37N3O7S

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(3R,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-yl N-[(1S,2R)-3-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamate

CAS Number

206361-99-1

PubChem ID

213039

InChI Key

CJBJHOAVZSMMDJ-HEXNFIEUSA-N

SMILES

[H][C@@]12CCO[C@@]1(OC[C@@H]2OC(N[C@H]([C@@H](CN(S(=O)(C3=CC=C(C=C3)N)=O)CC(C)C)O)CC4=CC=CC=C4)=O)[H]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 54.77 100

Preparing Stock Solutions for Darunavir

The following data is based on the product molecular weight 547.66.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.83 mL 9.13 mL 18.26 mL
5 mM 0.37 mL 1.83 mL 3.65 mL
10 mM 0.18 mL 0.91 mL 1.83 mL
50 mM 0.04 mL 0.18 mL 0.37 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for Darunavir

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Darunavir

For research use only

Customer Reviews for Darunavir (1)

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  • Interaction of darunavir with this stable portion of the protease
    Name: Anonymous
    Species: Human
    Verified Customer | Posted 12/01/2019
    Interaction of darunavir was studied with the stable portion of the protease. It was an attempt to finally identify interactions with HIV-1 protease and to be more resistant against HIV-1 protease mutations.
    Darunavir 6710

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