Catalog Number: 2096
Chemical Name: 8-Methyl-8-azabicyclo-3-endo[3.2.1]oct-3-yl-1,4-dihydro-2-oxo-3(2H)-quinazolinecarboxylic acid ester hydrochloride
Biological Activity
Selective muscarinic M3 receptor antagonist. In bovine tracheal smooth muscle, inhibits methacholine-dependent effects on cell proliferation and muscle contractility.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 50 mM in water and to 100 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Muscarinic M3 receptor-dependent regulation of airway smooth muscle contractile phenotype.
    Gosens et al.
    Br.J.Pharmacol., 2004;141:943
  2. Characterization of muscarinic receptors in guinea-pig uterus.
    Doods et al.
    Eur.J.Pharmacol., 1993;250:223
  3. Cholinergic contraction of the guinea pig lung strip is mediated by muscarinic M2-like receptors.
    Roffel et al.
    Eur.J.Pharmacol., 1993;250:267
  4. Muscarinic M3-receptors mediate cholinergic synergism of mitogenesis in airway smooth muscle.
    Gosens et al.
    Am.J.Respir.Cell Mol.Biol., 2003;28:257
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