Home / Other ER Stress/UPR Inhibitors / DBeQ

DBeQ

Catalog #: 4417
2 Citations Datasheet / COA / SDS

Discontinued Product

4417 has been discontinued.
View all Other ER Stress/UPR Inhibitors products.
DBeQ | CAS No. 177355-84-9 | Other ER Stress/UPR Inhibitors
1 Image
Description: Selective and reversible p97 ATPase inhibitor

Chemical Name: N2,N4-Bis(phenylmethyl)-2,4-quinazolinediamine

Purity: ≥99%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

DBeQ is a selective and reversible inhibitor of p97 ATPase (VCP, IC50 = 1.5 μM). Induces executioner caspases (caspase-3 and caspase-7) rapidly. Blocks the degradation of endoplasmic reticulum-associated degradation (ERAD) reporters; also blocks autophagosome maturation and promotes accumulation of LC3-II.

Technical Data

M.Wt:
340.42
Formula:
C22H20N4
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
177355-84-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways.
    Chou et al.
    Proc.Natl.Acad.Sci.USA, 2011;108:4834
  2. Development of p97 AAA ATPase inhibitors.
    Chou and Deshaies
    Autophagy, 2011;7:1091

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for DBeQ

The citations listed below are publications that use Tocris products. Selected citations for DBeQ include:

2 Citations: Showing 1 - 2

  1. Compounds activating VCP D1 ATPase enhance both autophagic and proteasomal neurotoxic protein clearance.
    Authors: Keith Et al.
    Nat Commun  2022;13:4146
  2. Caveolin-1 is an aggresome-inducing protein.
    Authors: Tiwari Et al.
    Sci Rep  2016;6:38681

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for DBeQ

There are currently no reviews for this product. Be the first to review DBeQ and earn rewards!

Have you used DBeQ?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.