DBeQ

Catalog # Availability Size / Price Qty
4417/10
4417/50
DBeQ | CAS No. 177355-84-9 | Other ER Stress/UPR Inhibitors
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Description: Selective and reversible p97 ATPase inhibitor

Chemical Name: N2,N4-Bis(phenylmethyl)-2,4-quinazolinediamine

Purity: ≥99%

Product Details
Citations (1)
Reviews (1)

Biological Activity

Selective and reversible inhibitor of p97 ATPase (VCP, IC50 = 1.5 μM). Induces executioner caspases (caspase-3 and caspase-7) rapidly. Blocks the degradation of endoplasmic reticulum-associated degradation (ERAD) reporters; also blocks autophagosome maturation and promotes accumulation of LC3-II.

Technical Data

M.Wt:
340.42
Formula:
C22H20N4
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
177355-84-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways.
    Chou et al.
    Proc.Natl.Acad.Sci.USA, 2011;108:4834
  2. Development of p97 AAA ATPase inhibitors.
    Chou and Deshaies
    Autophagy, 2011;7:1091

Product Datasheets

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Citation for DBeQ

The citations listed below are publications that use Tocris products. Selected citations for DBeQ include:

1 Citation: Showing 1 - 1

  1. Caveolin-1 is an aggresome-inducing protein.
    Authors: Tiwari Et al.
    Sci Rep  2016;6:38681

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Reviews for DBeQ

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DbeQ on Dictyostelium mTORC1 signalling
By Eleanor Warren on 05/23/2019
Species: Other

Treated Dictyostelium cells with DbeQ at 15 uM and 1.5 uM concentrations for 1 hour or 24 hours, and monitored p-4E-BP1 levels as a readout for mTORc1 activity. Did not see any significant difference from control


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