Chemical Name: N2,N4-Bis(phenylmethyl)-2,4-quinazolinediamine
Biological ActivityDBeQ is a selective and reversible inhibitor of p97 ATPase (VCP, IC50 = 1.5 μM). Induces executioner caspases (caspase-3 and caspase-7) rapidly. Blocks the degradation of endoplasmic reticulum-associated degradation (ERAD) reporters; also blocks autophagosome maturation and promotes accumulation of LC3-II.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways.
Chou et al.
Development of p97 AAA ATPase inhibitors.
Chou and Deshaies
Citation for DBeQ
The citations listed below are publications that use Tocris products. Selected citations for DBeQ include:
1 Citation: Showing 1 - 1
Caveolin-1 is an aggresome-inducing protein.
Authors: Tiwari Et al.
Sci Rep 2016;6:38681
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Treated Dictyostelium cells with DbeQ at 15 uM and 1.5 uM concentrations for 1 hour or 24 hours, and monitored p-4E-BP1 levels as a readout for mTORc1 activity. Did not see any significant difference from control