DBeQ

Tocris Bioscience | Catalog # 4417

Selective and reversible p97 ATPase inhibitor
Tocris Bioscience
Discontinued Product
4417 has been discontinued. View all Other ER Stress/UPR Inhibitors products.

Key Product Details

Description

Selective and reversible p97 ATPase inhibitor
View all Other ER Stress/UPR Inhibitors »

Product Description

DBeQ is a selective and reversible inhibitor of p97 ATPase (VCP, IC50 = 1.5 μM). Induces executioner caspases (caspase-3 and caspase-7) rapidly. Blocks the degradation of endoplasmic reticulum-associated degradation (ERAD) reporters; also blocks autophagosome maturation and promotes accumulation of LC3-II.

Product Specifications for DBeQ

Molecular Weight

340.42

Formula

C22H20N4

Storage

Store at +4°C

Purity

≥99% (HPLC)

Chemical Name

N2,N4-Bis(phenylmethyl)-2,4-quinazolinediamine

CAS Number

177355-84-9

PubChem ID

676352

InChI Key

QAIMUUJJAJBPCL-UHFFFAOYSA-N

SMILES

C12=CC=CC=C1N=C(NCC4=CC=CC=C4)N=C2NCC3=CC=CC=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 34.04 100

Preparing Stock Solutions for DBeQ

The following data is based on the product molecular weight 340.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.94 mL 14.69 mL 29.38 mL
5 mM 0.59 mL 2.94 mL 5.88 mL
10 mM 0.29 mL 1.47 mL 2.94 mL
50 mM 0.06 mL 0.29 mL 0.59 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for DBeQ

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for DBeQ

For research use only

Customer Reviews for DBeQ (1)

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  • DbeQ on Dictyostelium mTORC1 signalling
    Name: Eleanor Warren
    Species: Dictyostelium
    Assay Type: In Vitro
    Verified Customer | Posted 05/23/2019
    Treated Dictyostelium cells with DbeQ at 15 uM and 1.5 uM concentrations for 1 hour or 24 hours, and monitored p-4E-BP1 levels as a readout for mTORc1 activity. Did not see any significant difference from control
    DBeQ 4417

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