Catalog Number: 5077
Chemical Name: N-[3-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)oxy]-4-methylphenyl]-4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)benzamide dihydrochloride
Biological Activity
Selective discoidin domain receptor 1 (DDR1) tyrosine kinase inhibitor (IC50 values are 105 and 413 nM for DDR1 and DDR2 respectively). Inhibits integrin-induced DDR1 autophosphorylation in an osteosarcoma cell line.
External Portal Information
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of DDR1-IN-1 is reviewed on the chemical probes website.
Technical Data
  • M.Wt:
    625.51
  • Formula:
    C30H31F3N4O3.2HCl
  • Solubility:
    Soluble to 100 mM in water and to 50 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Desiccate at RT
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Discovery of a potent and selective DDR1 receptor tyrosine kinase inhibitor.
    Kim et al.
    ACS.Chem.Biol., 2013;8:2145
  2. Structural Mechanisms Determining Inhibition of the Collagen Receptor DDR1 by Selective and Multi-Targeted Type II Kinase Inhibitors.
    Canning et al.
    J.Mol.Biol., 2014;426:2457
Citations:

The citations listed below are publications that use Tocris products. Selected citations for DDR1-IN-1 dihydrochloride include:

1 Citations: Showing 1 - 1

  1. Novel cross talk between IGF-IR and DDR1 regulates IGF-IR trafficking, signaling and biological responses.
    Authors: Malaguarnera Et al.
    BMC Complement Altern Med 2015;6:16084

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