DDR1-IN-1 dihydrochloride

Tocris Bioscience | Catalog # 5077

Selective DDR1 inhibitor
Tocris Bioscience

Key Product Details

Description

Selective DDR1 inhibitor
View all Additional RTK Inhibitors »

Product Description

DDR1-IN-1 dihydrochloride is a selective discoidin domain receptor 1 (DDR1) tyrosine kinase inhibitor (IC50 values are 105 and 413 nM for DDR1 and DDR2 respectively). Inhibits integrin-induced DDR1 autophosphorylation in an osteosarcoma cell line.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of DDR1-IN-1 is reviewed on the chemical probes website.

Product Specifications for DDR1-IN-1 dihydrochloride

Molecular Weight

625.51

Formula

C30H31F3N4O3.2HCl

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

N-[3-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)oxy]-4-methylphenyl]-4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)benzamide dihydrochloride

CAS Number

1780303-76-5

PubChem ID

90489006

InChI Key

PBUOJKYQZINPKD-UHFFFAOYSA-N

SMILES

CC1=C(OC4=CC(CC(N5)=O)=C5C=C4)C=C(NC(C2=CC=C(CN3CCN(CC)CC3)C(C(F)(F)F)=C2)=O)C=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 62.55 100
DMSO 31.28 50

Preparing Stock Solutions for DDR1-IN-1 dihydrochloride

The following data is based on the product molecular weight 625.51.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.60 mL 7.99 mL 15.99 mL
5 mM 0.32 mL 1.60 mL 3.20 mL
10 mM 0.16 mL 0.80 mL 1.60 mL
50 mM 0.03 mL 0.16 mL 0.32 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 11 publications citing the usage of this product.

Product Documents for DDR1-IN-1 dihydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for DDR1-IN-1 dihydrochloride

For research use only

Citations for DDR1-IN-1 dihydrochloride

Customer Reviews for DDR1-IN-1 dihydrochloride (1)

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  • Collagen type 1 activated collagen receptor discoidin domain receptor
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: 3D Culture Matrix
    Verified Customer | Posted 02/21/2020
    10 μg/ml treat 24h and 48h
    DDR1-IN-1 dihydrochloride 5077

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