Selective discoidin domain receptor 1 (DDR1) tyrosine kinase inhibitor (IC50
values are 105 and 413 nM for DDR1 and DDR2 respectively). Inhibits integrin-induced DDR1 autophosphorylation in an osteosarcoma cell line.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Discovery of a potent and selective DDR1 receptor tyrosine kinase inhibitor.
Kim et al.
Structural Mechanisms Determining Inhibition of the Collagen Receptor DDR1 by Selective and Multi-Targeted Type II Kinase Inhibitors.
Canning et al.
The citations listed below are publications that use Tocris products. Selected citations for DDR1-IN-1 dihydrochloride include:
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