Chemical Name: N-[3-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)oxy]-4-methylphenyl]-4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)benzamide dihydrochloride
Biological ActivityDDR1-IN-1 dihydrochloride is a selective discoidin domain receptor 1 (DDR1) tyrosine kinase inhibitor (IC50 values are 105 and 413 nM for DDR1 and DDR2 respectively). Inhibits integrin-induced DDR1 autophosphorylation in an osteosarcoma cell line.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Complete Your Research
Discovery of a potent and selective DDR1 receptor tyrosine kinase inhibitor.
Kim et al.
Structural Mechanisms Determining Inhibition of the Collagen Receptor DDR1 by Selective and Multi-Targeted Type II Kinase Inhibitors.
Canning et al.
Citations for DDR1-IN-1 dihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for DDR1-IN-1 dihydrochloride include:
4 Citations: Showing 1 - 4
Silencing of sinusoidal DDR1 reduces murine liver metastasis by colon carcinoma.
Authors: Romayor Et al.
Sci Rep 2020;10:18398
Interaction of Discoidin Domain Receptor 1 with a 14-3-3-Beclin-1-Akt1 Complex Modulates Glioblastoma Therapy Sensitivity.
Authors: Vehlow Et al.
Cell Rep 2019;26:3672
Collagen Type 1 accelerates healing of ruptured fetal membranes.
Sci Rep 2018;8(1):696
Novel cross talk between IGF-IR and DDR1 regulates IGF-IR trafficking, signaling and biological responses.
Authors: Malaguarnera Et al.
BMC Complement Altern Med 2015;6:16084
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