Chemical Name: 4-Amino-1-(2-deoxy-β-D-erythro-pentofuranosyl)-1,3,5-triazin-2(1H)-one
Biological ActivityCytosine analog that once incorporated into DNA acts as a suicide substrate for DNA methyltransferase. Inhibits DNA methyltransferase and results in DNA hypomethylation and activation of silent genes. Chemotherapeutic agent; suppresses growth of human tumor cell lines. Demethylates differentiation-related genes; reverses embryonic stem cell differentiation.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Inhibition of DNA methylation by 5-aza-2'-deoxycytidine supresses the growth of human tumour cell lines.
Bender et al.
Cancer Res., 1998;58:95
Pharmacology of 5-aza-2'-deoxycytidine (decitabine).
Mutagenicity of 5-aza-2'-deoxycytidine is mediated by the mammalian DNA methyltransferase.
Jackson-Grusby et al.
Citations for Decitabine
The citations listed below are publications that use Tocris products. Selected citations for Decitabine include:
6 Citations: Showing 1 - 6
LKB1 loss links serine metabolism to DNA methylation and tumorigenesis.
Authors: Kottakis Et al.
Evaluation of azacit. and entinostat as sensitization agents to cytotoxic chemotherapy in preclinical models of non-small cell lung cancer.
Authors: Vendetti Et al.
Genes Dev 2015;6:56
Runx1 regulation of Pu.1 corepressor/coactivator exchange identifies specific molecular targets for leukemia differentiation therapy.
Authors: Gu Et al.
J Biol Chem 2014;289:14881
Down-regulation of HtrA1 activates the epithelial-mesenchymal transition and ATM DNA damage response pathways.
Authors: Wang Et al.
PLoS One 2012;7:e39446
Haploinsufficiency of Dnmt1 impairs leukemia stem cell function through derepression of bivalent chromatin domains.
Authors: Trowbridge Et al.
BMC Cancer 2012;26:344
Relation of DNA methylation of 5'-CpG island of ACSL3 to transplacental exposure to airborne polycyclic aromatic hydrocarbons and childhood asthma.
Authors: Perera Et al.
PLoS One 2009;4:e4488
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Cells were treated with 0.0015–30 μ decitabine