Decitabine

Catalog # Availability Size / Price Qty
2624/10
2624/50
Methyltransferase Inhibitors Small Molecule
1 Image
Description: DNA methyltransferase inhibitor
Alternative Names: 2'-Deoxy-5-azacytidine, 5-Aza-2'-deoxycytidine, NSC 127716

Chemical Name: 4-Amino-1-(2-deoxy-β-D-erythro-pentofuranosyl)-1,3,5-triazin-2(1H)-one

Purity: ≥99%

Product Details
Citations (6)
Reviews

Biological Activity

Cytosine analog that once incorporated into DNA acts as a suicide substrate for DNA methyltransferase. Inhibits DNA methyltransferase and results in DNA hypomethylation and activation of silent genes. Chemotherapeutic agent; suppresses growth of human tumor cell lines. Demethylates differentiation-related genes; reverses embryonic stem cell differentiation.

Technical Data

M.Wt:
228.21
Formula:
C8H12N4O4
Solubility:
Soluble to 50 mM in water and to 50 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
2353-33-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Inhibition of DNA methylation by 5-aza-2'-deoxycytidine supresses the growth of human tumour cell lines.
    Bender et al.
    Cancer Res., 1998;58:95
  2. Pharmacology of 5-aza-2'-deoxycytidine (decitabine).
    Momparler
    Semin.Hematol., 2005;42:S9
  3. Mutagenicity of 5-aza-2'-deoxycytidine is mediated by the mammalian DNA methyltransferase.
    Jackson-Grusby et al.
    Proc.Natl.Acad.Sci.USA, 1997;94:4681

Product Datasheets

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