Cytosine analog that once incorporated into DNA acts as a suicide substrate for DNA methyltransferase. Inhibits DNA methyltransferase and results in DNA hypomethylation and activation of silent genes. Chemotherapeutic agent; suppresses growth of human tumor cell lines. Demethylates differentiation-related genes; reverses embryonic stem cell differentiation.
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Inhibition of DNA methylation by 5-aza-2'-deoxycytidine supresses the growth of human tumour cell lines.
Bender et al.
Cancer Res., 1998;58:95
Pharmacology of 5-aza-2'-deoxycytidine (decitabine).
Mutagenicity of 5-aza-2'-deoxycytidine is mediated by the mammalian DNA methyltransferase.
Jackson-Grusby et al.
The citations listed below are publications that use Tocris products. Selected citations for Decitabine include:
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