Catalog Number: 4149
Alternate Names: U 90152
Chemical Name: 1-[3-[(1-Methylethyl)amino]-2-pyridinyl]-4-[[5-[(methylsulfonyl)amino]-1H-indol-2-yl]carbonyl]-piperazine monomethanesulfonate
Biological Activity
Non-nucleoside reverse transcriptase inhibitor (NNRTI). Selectively inhibits HIV-1 reverse transcriptase (RNA-dependent DNA polymerase) over other cellular polymerases (IC50 values are 0.26, 440 and >550 μM for HIV-1 reverse transcriptase, DNA polymerase α and DNA polymerase δ). Prevents HIV-1 spread in vivo and blocks viral replication in peripheral blood lymphocytes. Orally active.
Technical Data
  • M.Wt:
    552.67
  • Formula:
    C22H28N6O3S.CH3SO3H
  • Solubility:
    Soluble to 75 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at RT
  • CAS No:
    147221-93-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from Viiv.
Background References
  1. U-90152, a potent inhibitor of human immunodeficiency virus type 1 replication.
    Dueweke et al.
    Antimicrob.Agents Chemother., 1993;37:1127
  2. In vitro inhibition of human immunodeficiency virus type 1 by a combination of delavirdine (U-90152) with protease inhibitor U-75875 or interferon-alpha.
    Pagano and Chong
    J.Infect.Dis., 1995;171:61

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