Non-nucleoside reverse transcriptase inhibitor (NNRTI). Selectively inhibits HIV-1 reverse transcriptase (RNA-dependent DNA polymerase) over other cellular polymerases (IC50
values are 0.26, 440 and >550 μ
M for HIV-1 reverse transcriptase, DNA polymerase α
and DNA polymerase δ
). Prevents HIV-1 spread in vivo
and blocks viral replication in peripheral blood lymphocytes. Orally active.
Soluble to 75 mM in DMSO
Desiccate at RT
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Sold for research purposes under agreement from Viiv.
U-90152, a potent inhibitor of human immunodeficiency virus type 1 replication.
Dueweke et al.
Antimicrob.Agents Chemother., 1993;37:1127
In vitro inhibition of human immunodeficiency virus type 1 by a combination of delavirdine (U-90152) with protease inhibitor U-75875 or interferon-alpha.
Pagano and Chong