Chemical Name: 1-[3-[(1-Methylethyl)amino]-2-pyridinyl]-4-[[5-[(methylsulfonyl)amino]-1H-indol-2-yl]carbonyl]-piperazine monomethanesulfonate
Biological ActivityDelavirdine mesylate is a non-nucleoside reverse transcriptase inhibitor (NNRTI). Selectively inhibits HIV-1 reverse transcriptase (RNA-dependent DNA polymerase) over other cellular polymerases (IC50 values are 0.26, 440 and >550 μM for HIV-1 reverse transcriptase, DNA polymerase α and DNA polymerase δ). Prevents HIV-1 spread in vivo and blocks viral replication in peripheral blood lymphocytes. Orally active.
The technical data provided above is for guidance only.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
U-90152, a potent inhibitor of human immunodeficiency virus type 1 replication.
Dueweke et al.
Antimicrob.Agents Chemother., 1993;37:1127
In vitro inhibition of human immunodeficiency virus type 1 by a combination of delavi. (U-90152) with protease inhibitor U-75875 or IF.-alpha.
Pagano and Chong
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