Chemical Name: 3α,7α,15-Trihydroxy-12,13-epoxytrichothec-9-en-8-one
Biological Activity Tricothecene mycotoxin and potent protein synthesis inhibitor. Exhibits cytotoxic activity in vivo via the ribotoxic stress response. Induces p38-mediated gene expression and apoptosis in leukocytes; activity results in systemic expression of interleukin-6 (IL-6) and other proinflammatory cytokines. Also induces migration of NF-κB into the nucleus.
Soluble to 30 mM in ethanol
Store at +4°C
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