Catalog Number: 3976
Alternate Names: DON, Vomitoxin
Chemical Name: 3α,7α,15-Trihydroxy-12,13-epoxytrichothec-9-en-8-one
Biological Activity
Tricothecene mycotoxin and potent protein synthesis inhibitor. Exhibits cytotoxic activity in vivo via the ribotoxic stress response. Induces p38-mediated gene expression and apoptosis in leukocytes; activity results in systemic expression of interleukin-6 (IL-6) and other proinflammatory cytokines. Also induces migration of NF-κB into the nucleus.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 30 mM in ethanol
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Deoxynivalenol induces p38 interaction with the ribosome in monocytes and macrophages.
    Bae HK, Pestka JJ.
    Toxicol Sci
  2. Role of GRP78/BiP degradation and ER stress in deoxynivalenol-induced interleukin-6 upregulation in the macrophage.
    Shi et al.
    Toxicol.Sci., 2009;109:247
  3. Lutein protects HT-29 cells against deoxynivalenol-induced oxidative stress and apoptosis: prevention of NF-κB nuclear localization and down regulation of NF-κB and cyclo-oxygenase-2 expression.
    Krishnaswamy et al.
    Free Radic.Biol.Med., 2010;49:50
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