Tricothecene mycotoxin and potent protein synthesis inhibitor. Exhibits cytotoxic activity in vivo
via the ribotoxic stress response. Induces p38-mediated gene expression and apoptosis in leukocytes; activity results in systemic expression of interleukin-6 (IL-6) and other proinflammatory cytokines. Also induces migration of NF-κ
B into the nucleus.
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Deoxynivalenol induces p38 interaction with the ribosome in monocytes and macrophages.
Bae HK, Pestka JJ.
Role of GRP78/BiP degradation and ER stress in deoxynivalenol-induced interleukin-6 upregulation in the macrophage.
Shi et al.
Lutein protects HT-29 cells against deoxynivalenol-induced oxidative stress and apoptosis: prevention of NF-κB nuclear localization and down regulation of NF-κB and cyclo-oxygenase-2 expression.
Krishnaswamy et al.
Free Radic.Biol.Med., 2010;49:50