Deoxynivalenol

Key Product Details

Product Description

Deoxynivalenol is a tricothecene mycotoxin and potent protein synthesis inhibitor. Exhibits cytotoxic activity in vivo via the ribotoxic stress response. Induces p38-mediated gene expression and apoptosis in leukocytes; activity results in systemic expression of interleukin-6 (IL-6) and other proinflammatory cytokines. Also induces migration of NF-κB into the nucleus.

Product Specifications for Deoxynivalenol

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Deoxynivalenol

The following data is based on the product molecular weight 296.32.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

5 4 3 2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.3 mM	11.25 mL	56.25 mL	112.49 mL
1.5 mM	2.25 mL	11.25 mL	22.50 mL
3 mM	1.12 mL	5.62 mL	11.25 mL
15 mM	0.22 mL	1.12 mL	2.25 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 5 publications citing the usage of this product.

• Shi Role of GRP78/BiP degradation and ER stress in deoxynivalenol-induced interleukin-6 upregulation in the macrophage. Toxicol.Sci. 2009 PMID: 19336499
• Krishnaswamy Lutein protects HT-29 cells against deoxynivalenol-induced oxidative stress and apoptosis: prevention of NF-κB nuclear localization and down regulation of NF-κB and cyclo-oxygenase-2 expression. Free Radic.Biol.Med. 2010 PMID: 20347963
• Bae and Pestka Deoxynivalenol induces p38 interaction with the ribosome in monocytes and macrophages. Toxicol.Sci. 2008 PMID: 18502741

Product Documents for Deoxynivalenol