Chemical Name: 3α,7α,15-Trihydroxy-12,13-epoxytrichothec-9-en-8-one
Biological ActivityTricothecene mycotoxin and potent protein synthesis inhibitor. Exhibits cytotoxic activity in vivo via the ribotoxic stress response. Induces p38-mediated gene expression and apoptosis in leukocytes; activity results in systemic expression of interleukin-6 (IL-6) and other proinflammatory cytokines. Also induces migration of NF-κB into the nucleus.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Deoxynivalenol induces p38 interaction with the ribosome in monocytes and macrophages.
Bae HK, Pestka JJ.
Role of GRP78/BiP degradation and ER stress in deoxynivalenol-induced interleukin-6 upregulation in the macrophage.
Shi et al.
Lutein protects HT-29 cells against deoxynivalenol-induced oxidative stress and apoptosis: prevention of NF-κB nuclear localization and down regulation of NF-κB and cyclo-oxygenase-2 expression.
Krishnaswamy et al.
Free Radic.Biol.Med., 2010;49:50
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for Deoxynivalenol
There are currently no reviews for this product. Be the first to review Deoxynivalenol and earn rewards!
Have you used Deoxynivalenol?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image