Catalog Number: 3396
Biological Activity
Synthetic vasopressin analog that acts as an agonist at V1B and V2 receptors (EC50 values are 11.4 and 23.9 nM and Ki values are 5.84 and 65.9 nM respectively). Prevents polycystic kidney disease formation and exhibits antidiuretic, antiproliferative, hemostatic and hypotensive activity in vivo.
Technical Data
  • M.Wt:
    1069.22
  • Formula:
    C46H64N14O12S2
  • Sequence:
    XYFQNCPRG

    (Modifications: X = Mpr, Arg-8 = D-Arg, Gly-9 = C-terminal amide, Cyclized = X-1 - Cys-6)

  • Solubility:
    Soluble to 4 mg/ml in water
  • Storage:
    Store at -20°C
  • CAS No:
    16679-58-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. 1-Desamino-8-D-arginine vasopressin (DDAVP) as an agonist on V1b vasopressin receptor.
    Saito et al.
    Biochem.Pharmacol., 1997;53:1711
  2. Desmopressin and other synthetic vasopressin analogues in cancer treatment.
    Gomez et al.
    Bull.Cancer, 2006;93:E7
  3. Vasopressin antagonists in polycystic kidney disease.
    Torres
    Semin.Nephrol., 2008;28:306

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