Catalog Number: 1126
Chemical Name: (11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methyl-pregna-1,4-diene-3,20-dione
Biological Activity
Glucocorticoid; anti-inflammatory. Reduces levels of activated NF-κB in immature dendritic cells (DCs) and inhibits differentiation into mature DCs. Induces differentiation of human mesenchymal stem cells (MSCs). Also induces autophagy in acute lymphoblastic leukemia (ALL) cell lines.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References

  1. Kishimoto T et al.
    Leucocyte Typing VI. Garland Publishing Inc. London.
  2. Short bouts of mechanical loading are as effective as dexamethasone at inducing matrix production by human bone marrow mesenchymal stem cell.
    Sittichokechaiwut et al.
    Eur.Cell Mater., 2010;20:45
  3. Dexamethasone inhibits dendritic cell maturation by redirecting differentiation of a subset of cells.
    Matasic et al.
    J.Leukoc.Biol., 1999;66:909
  4. Cell death induced by dexamethasone in lymphoid leukemia is mediated through initiation of autophagy.
    Laane et al.
    Cell Death Differ., 2009;16:1018
  5. Effects of dexamethasone and cyclosporin A on the accumulation of eosinophils in acute cutaneous inflammation in the guinea-pig.
    Teixeira et al.
    Br.J.Pharmacol., 1996;118:317

The citations listed below are publications that use Tocris products. Selected citations for Dexamethasone include:

Showing Results 1 - 3 of 3

  1. Synergistic Anti-Tumor Activity of EZH2 Inhibitors and Glucocorticoid Receptor Agonists in Models of Germinal Center Non-Hodgkin Lymphomas.
    Authors: Knutson Et al.
    PLoS One
  2. The human tissue-biomaterial interface: a role for PPARγ-dependent glucocorticoid receptor activation in regulating the CD163+ M2 macrophage phenotype.
    Authors: Bullers Et al.
    Tissue Eng Part A
  3. Riluzole elevates GLT-1 activity and levels in striatal astrocytes.
    Authors: Carbone Et al.
    J Neurosci
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