Chemical Name: (11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methyl-pregna-1,4-diene-3,20-dione
Biological ActivityGlucocorticoid; anti-inflammatory. Reduces levels of activated NF-κB in immature dendritic cells (DCs) and inhibits differentiation into mature DCs. Induces differentiation of human mesenchymal stem cells (MSCs). Also used in the generation of liver organoids. Induces autophagy in acute lymphoblastic leukemia (ALL) cell lines. Acts as viral transduction enhancer by promoting intracellular shuttling of HIV-1 pre-integration complex to the nucleus. Additionally Dexamethasone pretreatment in vivo suppresses adaptive immune response to recombinant adenoviral gene transfer vectors.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Long-term culture of genome-stable bipotent stem cells from adult human liver.
Huch M, Gehart H, van Boxtel R, Hamer K, Blokzijl F, Verstegen M, Ellis E, van Wenum M, Fuchs S, de Ligt J, van de Wetering M, Sasaki N, Boers S, Kemperman H, de Jonge J, Ijzermans J, Nieuwenhuis E, Hoekstra R, Strom S, Vries R, van der Laan L, Cuppen E, Clevers H
Dexamethasone inhibits dendritic cell maturation by redirecting differentiation of a subset of cells.
Matasic et al.
Cell death induced by dexameth. in lymphoid leukemia is mediated through initiation of autophagy.
Laane et al.
Cell Death Differ., 2009;16:1018
Effects of dexameth. and cyclosporin A on the accumulation of eosinophils in acute cutaneous inflammation in the guinea-pig.
Teixeira et al.
Short bouts of mechanical loading are as effective as dexameth. at inducing matrix production by human bone marrow mesenchymal stem cell.
Sittichokechaiwut et al.
Eur.Cell Mater., 2010;20:45
The effect of dexamethasone on lentiviral vector infection is associated with importin α.
Deng et al.
Transient pretreatment with glucocorticoid ablates innate toxicity of systemically delivered adenoviral vectors without reducing efficacy.
Seregin et al.
Citations for Dexamethasone
The citations listed below are publications that use Tocris products. Selected citations for Dexamethasone include:
8 Citations: Showing 1 - 8
Single cell analysis of human foetal liver captures the transcriptional profile of hepatobiliary hybrid progenitors.
Authors: Segal Et al.
Nat Commun 2019;10:3350
Inflammatory Cytokine TNFα Promotes the Long-Term Expansion of Primary Hepatocytes in 3D Culture.
Authors: Peng Et al.
Mineralocorticoid Antagonist Improves Glucocorticoid Receptor Signaling and DEX Analgesia in an Animal Model of Low Back Pain.
Authors: Ibrahim Et al.
Front Cell Neurosci 2018;12:453
Directed differentiation of human induced pluripotent stem cells into functional cholangiocyte-like cells.
Authors: Sampaziotis Et al.
Nat Protoc 2017;12:814
Hierarchical glucocorticoid-endocannabinoid interplay regulates the activation of the nucleus accumbens by insulin.
Authors: Pinheiro Et al.
Brain Res.Bull. 2016;124:222
Synergistic Anti-Tumor Activity of EZH2 Inhibitors and Glucocorticoid Receptor Agonists in Models of Germinal Center Non-Hodgkin Lymphomas.
Authors: Knutson Et al.
PLoS One 2014;9:e111840
The human tissue-biomaterial interface: a role for PPARγ-dependent glucocorticoid receptor activation in regulating the CD163+ M2 macrophage phenotype.
Authors: Bullers Et al.
Tissue Eng Part A 2014;20:2390
R.zole elevates GLT-1 activity and levels in striatal astrocytes.
Authors: Carbone Et al.
J Neurosci 2012;60:42613
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