Dexamethasone

Tocris Bioscience | Catalog # 1126

Anti-inflammatory glucocorticoid
Tocris Bioscience

Key Product Details

Description

Anti-inflammatory glucocorticoid
View all Glucocorticoid Receptor Compounds »

Product Description

Dexamethasone is a glucocorticoid; anti-inflammatory. Reduces levels of activated NF-κB in immature dendritic cells (DCs) and inhibits differentiation into mature DCs. Induces differentiation of human mesenchymal stem cells (MSCs). Also used in the generation of liver organoids. Induces autophagy in acute lymphoblastic leukemia (ALL) cell lines. Acts as viral transduction enhancer by promoting intracellular shuttling of HIV-1 pre-integration complex to the nucleus. Additionally Dexamethasone pretreatment in vivo suppresses adaptive immune response to recombinant adenoviral gene transfer vectors.

Dexamethasone synthesized to Ancillary Material Grade also available.

Tocris products are for biomedical research use only. They are not intended for human or veterinary use.

Product Specifications for Dexamethasone

Molecular Weight

392.47

Formula

C22H29FO5

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

(11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methyl-pregna-1,4-diene-3,20-dione

CAS Number

50-02-2

PubChem ID

9830630

InChI Key

UREBDLICKHMUKA-WNYCSEIESA-N

SMILES

O=C1C=C[C@@]2(C)C(CC[C@]3([H])[C@]2(F)[C@@H](O)C[C@@]4(C)[C@@]3([H])C[C@@H](C)[C@]4(O)C(CO)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.25 100

Preparing Stock Solutions for Dexamethasone

The following data is based on the product molecular weight 392.47.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.55 mL 12.74 mL 25.48 mL
5 mM 0.51 mL 2.55 mL 5.10 mL
10 mM 0.25 mL 1.27 mL 2.55 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

Calculators

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Product Documents for Dexamethasone

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Dexamethasone

For research use only

Customer Reviews for Dexamethasone (2)

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  • Dexamethasone used in HUDEP-2 cell culture
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: HUDEP-2
    Verified Customer | Posted 12/11/2023
    Dexamethasone (Cat. No. 1126) was used in HUDEP-2 (erythroid progenitor cells) cell culture media. Image shows culture of the erythroid progenitor cell line HUDEP-2.
    Dexamethasone 1126
  • Great anti-inflammatory drug
    Name: Luiz Alexandre Magno
    Species: Mouse
    Assay Type: In Vivo
    Verified Customer | Posted 02/17/2022
    I used this drug to decrease the levels of IL-1, which is a proinflammatory cytokine. By doing this, we can explore the outcome of signalling pathways that can cause brain disease
    Dexamethasone 1126

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