DFHO
Chemical Name: 4-(3,5-Difluoro-4-hydroxybenzylidene)-1-methyl-5-oxo-4,5-dihydro-1H-imidazole-2-carbaldehyde oxime
Purity: ≥98%
Biological Activity
DFHO is a mimic of red fluorescent protein (RFP) fluorophore for imaging RNA in living cells. Fluorescence is activated by binding to Corn aptamer (Kd = 70 nM). Excitation/emission maxima (λ) = 505/545 nm; extinction coefficient = 29000 M-1 cm-1.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Imaging RNA polymerase III transcription using a photostable RNA-fluorophore complex.
Song et al.
Nat.Chem.Biol., 2017;13:1187 -
A homodimer interface without base pairs in an RNA mimic of red fluorescent protein.
Warner et al.
Nat.Chem.Biol., 2017;13:1195
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