Catalog Number: 2761
Alternate Names: Eflornithine
Chemical Name: DL-2-(Difluoromethyl)-ornithine hydrochloride
Biological Activity
Irreversible inhibitor of ornithine decarboxylase (ODC) that inhibits polyamine biosynthesis. Displays antiapoptotic, antiangiogenic and antiparasitic activity. Induces re-expression of aberrantly silenced tumor suppressor genes when used in combination with oligoamine analogs.
Technical Data
  • M.Wt:
    218.63
  • Formula:
    C6H12F2N2O2.HCl
  • Solubility:
    Soluble to 75 mM in water
  • Storage:
    Desiccate at RT
  • CAS No:
    68278-23-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Revival of 2-(difluoromethyl)ornithine (DFMO), an inhibitor of polyamine biosynthesis, as a cancer chemopreventative agent.
    Raul
    Biochem.Soc.Trans., 2007;35:353
  2. Oligoamine analogues in combination with 2-difluoromethylornithine synergistically induce re-expression of aberrantly silenced tumour-suppressor genes.
    Wu et al.
    Biochem.J., 2012;442:693
  3. Sensitivity of Trypanosomatid protozoa to DFMO and metabolic turnover of ornithine decarboxylase.
    Carrillo et al.
    Biochem.Biophys.Res.Comm., 2000;279:663

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