Chemical Name: DL-2-(Difluoromethyl)-ornithine hydrochloride
Biological ActivityDFMO is an irreversible inhibitor of ornithine decarboxylase (ODC) that inhibits polyamine biosynthesis. Displays antiapoptotic, antiangiogenic and antiparasitic activity. Induces re-expression of aberrantly silenced tumor suppressor genes when used in combination with oligoamine analogs.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Oligoamine analogues in combination with 2-difluoromethylornithine synergistically induce re-expression of aberrantly silenced tumour-suppressor genes.
Wu et al.
Revival of 2-(difluoromethyl)ornithine (DFMO), an inhibitor of polyamine biosynthesis, as a cancer chemopreventative agent.
Sensitivity of Trypanosomatid protozoa to DFMO and metabolic turnover of ornithine decarboxylase.
Carrillo et al.
Citation for DFMO
The citations listed below are publications that use Tocris products. Selected citations for DFMO include:
1 Citation: Showing 1 - 1
Tissue damage induces a conserved stress response that initiates quiescent muscle stem cell activation.
Authors: Machado Et al.
Cell Stem Cell 2021;28:1
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