DFMO

Catalog # Availability Size / Price Qty
2761/10
2761/50
DFMO | CAS No. 68278-23-9 | Decarboxylase Inhibitors
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Description: Ornithine decarboxylase inhibitor
Alternative Names: Eflornithine

Chemical Name: DL-2-(Difluoromethyl)-ornithine hydrochloride

Product Details
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Biological Activity

Irreversible inhibitor of ornithine decarboxylase (ODC) that inhibits polyamine biosynthesis. Displays antiapoptotic, antiangiogenic and antiparasitic activity. Induces re-expression of aberrantly silenced tumor suppressor genes when used in combination with oligoamine analogs.

Technical Data

Formula:
C6H12F2N2O2.HCl
Solubility:
Soluble to 75 mM in water
Storage:
Store the unopened product at room temperature. Do not use past expiration date.
CAS No:
68278-23-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Oligoamine analogues in combination with 2-difluoromethylornithine synergistically induce re-expression of aberrantly silenced tumour-suppressor genes.
    Wu et al.
    Biochem.J., 2012;442:693
  2. Revival of 2-(difluoromethyl)ornithine (DFMO), an inhibitor of polyamine biosynthesis, as a cancer chemopreventative agent.
    Raul
    Biochem.Soc.Trans., 2007;35:353
  3. Sensitivity of Trypanosomatid protozoa to DFMO and metabolic turnover of ornithine decarboxylase.
    Carrillo et al.
    Biochem.Biophys.Res.Comm., 2000;279:663

Product Datasheets

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