DG 172 dihydrochloride

Catalog # Availability Size / Price Qty
5566/10
5566/50
Cat.No. 5566 - DG 172 dihydrochloride | C20H20BrN3.2HCl | CAS No. 1361504-77-9
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Description: Potent PPARβ/δ inverse agonist; promotes BMC differentiation

Chemical Name: (αZ)-2-Bromo-α-[[4-(4-methyl-1-piperazinyl)phenyl]methylene]benzeneacetonitrile dihydrochloride

Purity: ≥98%

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Biological Activity

Potent PPARβ/δ inverse agonist (IC50 = 26.9 nM). Inhibits Angptl4 gene expression in mouse myoblasts (IC50 = 9.5 nM) in vitro. Also augments GM-CSF/IL-4-induced differentiation of mature dendritic cells from bone marrow cells in culture. Orally available.

Technical Data

M.Wt:
455.22
Formula:
C20H20BrN3.2HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
1361504-77-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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