Catalog Number: 1218
Chemical Name: N-Pentanoyl-2-benzyltryptamine
Biological Activity
A relatively potent MT2 melatonin receptor antagonist (pKi value = 8.03), displaying 89- and 229-fold selectivity over MT1 and GPR50 (melatonin-related orphan receptor) respectively.
Technical Data
  • M.Wt:
    334.46
  • Formula:
    C22H26N2O
  • Solubility:
    Soluble to 100 mM in DMSO
  • Storage:
    Store at RT
  • CAS No:
    220339-00-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Molecular and pharmacological evidence for MT1 melatonin receptor subtype in the tail artery of juvenile Wistar rats.
    Ting et al.
    Br.J.Pharmacol., 1999;127:987
  2. Comparison of the relationships of melatonin receptor agonists and antagonists; lengthening the N-acyl side chain has differing effects on potency on Xenopus melanophores.
    Teh and Sugden
    Naunyn Schmiedebergs Arch.Pharmacol., 1998;358:522
Citations:

The citations listed below are publications that use Tocris products. Selected citations for DH 97 include:

2 Citations: Showing 1 - 2
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  1. Melatonin inhibits tachykinin NK2 receptor-triggered 5-HT release from guinea pig isolated colonic mucosa.
    Authors: Kojima Et al.
    Br J Pharmacol 2011;162:1179
  2. Melatonin-induced calcium signaling in clusters of human and rat duodenal enterocytes.
    Authors: Sjöblom Et al.
    BMC Neurosci 2003;284:G1034

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