Biological ActivityDH 97 is a relatively potent MT2 melatonin receptor antagonist (pKi value = 8.03), displaying 89- and 229-fold selectivity over MT1 and GPR50 (melatonin-related orphan receptor) respectively.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Comparison of the relationships of melatonin receptor agonists and antagonists; lengthening the N-acyl side chain has differing effects on potency on Xenopus melanophores.
Teh and Sugden
Naunyn Schmiedebergs Arch.Pharmacol., 1998;358:522
Molecular and pharmacological evidence for MT1 melatonin receptor subtype in the tail artery of juvenile Wistar rats.
Ting et al.
Citations for DH 97
The citations listed below are publications that use Tocris products. Selected citations for DH 97 include:
2 Citations: Showing 1 - 2
Melatonin inhibits tachykinin NK2 receptor-triggered 5-HT release from guinea pig isolated colonic mucosa.
Authors: Kojima Et al.
Br J Pharmacol 2011;162:1179
Melatonin-induced calcium signaling in clusters of human and rat duodenal enterocytes.
Authors: Sjöblom Et al.
BMC Neurosci 2003;284:G1034
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