Dibutyryl-cAMP, sodium salt
Chemical Name: N6,O2'-Dibutyryl adenosine 3',5'-cyclic monophosphate sodium salt
Biological ActivityDibutyryl-cAMP sodium salt is a cell-permeable analog of cAMP that activates cAMP-dependent protein kinases and is a phosphodiesterase inhibitor. Combined with other reagents, dibutyryl-cAMP promotes differentiation of neural stem/progenitor cells (NSPCs) and other cell lines and increases survival rates of NSPCs and differentiation into neurons in vivo. Promotes neurite outgrowth in cell cultures. Dibutyryl-cAMP has anti-inflammatory activity and is used to promote wound healing. Choline acetyltransferase and vesicular acetylcholine transporter mRNA are increased in cells treated with dibutyryl-cAMP.
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Transcriptional comparison of human induced and primary midbrain DArgic neurons.
Xia et al.
Protein kinase A induces recruitment of active Na+,K+-ATPase units to the plasma membrane of rat proximal convoluted tubule cells.
Carranza et al.
Lack of correlation between activation of cyclic AMP-dependent protein kinase and inhibition of contraction of rat vas deferens by cyclic AMP analogs
Hei et al.
Differential expression of dystrophin isoforms and utrophin during dibutyryl-cAMP-induced morphological differentiation of rat brain astrocytes.
Imamura et al.
Citations for Dibutyryl-cAMP, sodium salt
The citations listed below are publications that use Tocris products. Selected citations for Dibutyryl-cAMP, sodium salt include:
4 Citations: Showing 1 - 4
Discovery of small molecules that normalize the transcriptome and enhance cysteine cathepsin activity in progranulin-deficient microglia.
Authors: Telpoukhovskaia Et al.
Sci Rep 2020;10
Efficient Generation of CA3 Neurons from Human Pluripotent Stem Cells Enables Modeling of Hippocampal Connectivity In Vitro.
Authors: Sarkar Et al.
Cell Stem Cell 2018;22:684
The role of protein kinase A in the ethanol-induced increase in spontaneous GABA release onto cerebellar Purkinje neurons.
Authors: Kelm Et al.
J Neurophysiol 2008;100:3417
Activation of inward rectifier K+ channels by hypoxia in rabbit coronary arterial smooth muscle cells.
Authors: Park Et al.
Am J Physiol Heart Circ Physiol 2005;289:H2461
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