Dibutyryl-cAMP, sodium salt

Key Product Details

Product Description

Dibutyryl-cAMP sodium salt is a cell-permeable analog of cAMP that activates cAMP-dependent protein kinases and is a phosphodiesterase inhibitor. Combined with other reagents, dibutyryl-cAMP promotes differentiation of neural stem/progenitor cells (NSPCs) and other cell lines (see our protocol below) and increases survival rates of NSPCs and differentiation into neurons in vivo. Promotes neurite outgrowth in cell cultures. Dibutyryl-cAMP has anti-inflammatory activity and is used to promote wound healing. Choline acetyltransferase and vesicular acetylcholine transporter mRNA are increased in cells treated with dibutyryl-cAMP.

For more information about how Dibutyryl-cAMP, sodium salt may be used, see our protocol: Generating Midbrain Dopaminergic Neurons from hPSCs

Product Specifications for Dibutyryl-cAMP, sodium salt

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Dibutyryl-cAMP, sodium salt

The following data is based on the product molecular weight 491.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.04 mL	10.18 mL	20.35 mL
5 mM	0.41 mL	2.04 mL	4.07 mL
10 mM	0.20 mL	1.02 mL	2.04 mL
50 mM	0.04 mL	0.20 mL	0.41 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 40 publications citing the usage of this product.

• Kim Effects of dibutyryl cyclic-AMP on survival and neuronal differentiation of neural stem/progenitor cells transplanted into spinal cord injured rats. PLoS One 2011 PMID: 21738784
• Xia Transcriptional comparison of human induced and primary midbrain DArgic neurons. Sci.Rep. 2016 PMID: 26842779
• Hei Lack of correlation between activation of cyclic AMP-dependent protein kinase and inhibition of contraction of rat vas deferens by cyclic AMP analogs Mol.Pharmacol. 1991 PMID: 1847496
• Imamura Differential expression of dystrophin isoforms and utrophin during dibutyryl-cAMP-induced morphological differentiation of rat brain astrocytes. Proc.Natl.Acad.Sci.U.S.A. 1998 PMID: 9600931
• Carranza Protein kinase A induces recruitment of active Na⁺,K⁺-ATPase units to the plasma membrane of rat proximal convoluted tubule cells. J.Physiol. 1998 PMID: 9679177

Product Documents for Dibutyryl-cAMP, sodium salt