Catalog Number: 1141
Chemical Name: N6,O2'-Dibutyryl adenosine 3',5'-cyclic monophosphate sodium salt
Biological Activity
Cell-permeable analog of cAMP; activates cAMP-dependent protein kinases. Promotes differentiation of dopaminergic neurons (iDA) from hPSCs in combination with other reagents.
Technical Data
  • M.Wt:
    491.37
  • Formula:
    C18H23N5NaO8P
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Desiccate at -20°C
  • CAS No:
    16980-89-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Protein kinase A induces recruitment of active Na+,K+-ATPase units to the plasma membrane of rat proximal convoluted tubule cells.
    Carranza et al.
    J.Physiol., 1998;511:235
  2. Lack of correlation between activation of cyclic AMP-dependent protein kinase and inhibition of contraction of rat vas deferens by cyclic AMP analogs
    Hei et al.
    Mol.Pharmacol., 1991;39:233
  3. Differential expression of dystrophin isoforms and utrophin during dibutyryl-cAMP-induced morphological differentiation of rat brain astrocytes.
    Imamura et al.
    Proc.Natl.Acad.Sci.U.S.A., 1998;95:6139
  4. Transcriptional comparison of human induced and primary midbrain dopaminergic neurons.
    Xia et al.
    Sci.Rep., 2016;6:20270
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Dibutyryl-cAMP, sodium salt include:

1 Citations: Showing 1 - 1

  1. Activation of inward rectifier K+ channels by hypoxia in rabbit coronary arterial smooth muscle cells.
    Authors: Park Et al.
    Am J Physiol Heart Circ Physiol 2005;289:H2461

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