Digoxin

Tocris Bioscience | Catalog # 4583

Na+/K+ ATPase inhibitor
Tocris Bioscience

Key Product Details

Description

Na+/K+ ATPase inhibitor
View all Na+/K+ ATPase Inhibitors »

Product Description

Digoxin is an inhibits membrane-bound α-subunits of the Na+/K+ ATPase pump in myocytes. Increases RGS2 protein levels in primary vascular smooth muscle cells through an Na+/K+ ATPase pump-dependent mechanism. Also exhibits anti-MERS-CoV activity in Vero cells in vitro (IC50 = 0.17 μM).

Product Specifications for Digoxin

Molecular Weight

780.94

Formula

C41H64O14

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

4-[(3S,5R,8R,9S,10S,12R,13S,14S)-3-[(2S,4S,5R,6R)-5-[(2S,4S,5R,6R)-5-[(2S,4S,5R,6R)-4,5-Dihydroxy-6-methyloxan-2-yl]oxy-4-hydroxy-6-methyl-oxan-2-yl]oxy-4-hydroxy-6-methyl-oxan-2-yl]oxy-12,14-dihydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-5H-furan-2-one

CAS Number

20830-75-5

PubChem ID

12940973

InChI Key

LTMHDMANZUZIPE-PUGKRICDSA-N

SMILES

O=C1OCC([C@H]2CC[C@]3(O)[C@]4([H])CC[C@@]5(C[C@H](CC[C@@]5([C@]4(C[C@H]([C@@]32C)O)[H])C)O[C@@]6(O[C@@H]([C@H]([C@H](C6)O)O[C@]7(C[C@@H]([C@@H]([C@H](O7)C)O[C@@]8(O[C@@H]([C@H]([C@H](C8)O)O)C)[H])O)[H])C)[H])[H])=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 78.09 100

Preparing Stock Solutions for Digoxin

The following data is based on the product molecular weight 780.94.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.28 mL 6.40 mL 12.81 mL
5 mM 0.26 mL 1.28 mL 2.56 mL
10 mM 0.13 mL 0.64 mL 1.28 mL
50 mM 0.03 mL 0.13 mL 0.26 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 32 publications citing the usage of this product.

Product Documents for Digoxin

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Digoxin

For research use only

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