Digoxin

Catalog # Availability Size / Price Qty
4583/50
Digoxin | CAS No. 20830-75-5 | Na+/K+ ATPase Inhibitors
1 Image
Description: Na+/K+ ATPase inhibitor

Chemical Name: 4-[(3S,5R,8R,9S,10S,12R,13S,14S)-3-[(2S,4S,5R,6R)-5-[(2S,4S,5R,6R)-5-[(2S,4S,5R,6R)-4,5-Dihydroxy-6-methyloxan-2-yl]oxy-4-hydroxy-6-methyl-oxan-2-yl]oxy-4-hydroxy-6-methyl-oxan-2-yl]oxy-12,14-dihydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-5H-furan-2-one

Purity: ≥98%

Product Details
Citations (2)
Reviews

Biological Activity

Digoxin is an inhibits membrane-bound α-subunits of the Na+/K+ ATPase pump in myocytes. Increases RGS2 protein levels in primary vascular smooth muscle cells through an Na+/K+ ATPase pump-dependent mechanism. Also exhibits anti-MERS-CoV activity in Vero cells in vitro (IC50 = 0.17 μM).

Technical Data

M.Wt:
780.94
Formula:
C41H64O14
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at RT
CAS No:
20830-75-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Endogenous digitalis-like factors. An historical overview.
    Buckalew
    Front.Biosci., 2005;10:2325
  2. Digoxin in the management of cardiovascular disorders.
    Gheorghiade et al.
    Circulation, 2004;109:2959
  3. Cardiotonic steroids stabilize regulator of g protein signaling 2 protein levels.
    Sjogren et al.
    Mol.Pharmacol., 2012;82:500

Product Datasheets

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Citations for Digoxin

The citations listed below are publications that use Tocris products. Selected citations for Digoxin include:

2 Citations: Showing 1 - 2

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