Catalog Number: 0475
Chemical Name: 9,10-Dihydro-12'-hydroxy-2'-methyl-5'-(phenylmethyl)ergotaman-3',6',18-trione mesylate
Biological Activity
Partial α-adrenergic agonist. Partial D2 dopaminergic receptor agonist. Competitive 5-HT antagonist.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Further analysis of the inhibitory effects of dihydroergotamine, cyproheptadine and ketanserin on the responses of the rat aorta to 5-hydroxytryptamine.
    Doggrell et al.
    J.Auton.Pharmacol., 1992;12:223
  2. Agonistic properties of alniditan, sumatriptan and dihydroergotamine on human 5-HT1B and 5-HT1D receptors expressed in various mammalian cell lines.
    Lesage et al.
    Br.J.Pharmacol., 1998;123:1655
  3. Carotid vascular effects of ergotamine and dihydroergotamine in the pig: no exclusive mediation via 5-HT1-like receptors.
    de Boer et al.
    Br.J.Pharmacol., 1991;104:183
  4. Effects of S9977 and dihydroergotamine in an animal experimental model for migraine.
    Villalon et al.
    Pharmacol.Res., 1992;25:125
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