Dihydroergotoxine mesylate

Name: Dihydroergotoxine mesylate
Brand: Tocris Bioscience
SKU: 0505

Tocris Bioscience | Catalog # 0505

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Product Documents

Binds to GABAA receptor Cl- channel; allosteric modulator of benzodiazepine site

Discontinued Product

0505 has been discontinued. View all GABA-A Receptor Benzodiazepines products.

Technical Data
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Product Description
Product Specifications
Calculators
Background References
Product Documents
Specific Notices
Research Areas

Key Product Details

Description

Binds to GABAA receptor Cl- channel; allosteric modulator of benzodiazepine site

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Product Description

Dihydroergotoxine mesylate is a complex of closely related alkaloid salts. Binds with high affinity to the GABA_A receptor Cl^- channel, producing an allosteric interaction with the benzodiazepine site. Also interacts with central dopaminergic, serotonergic and adrenergic (α₁) receptors. Displays antiproliferative activity in vitro (IC₅₀ = 18 - 38 μM in prostate cancer cells) and exhibits cognition-enhancing, anticonvulsant and sedative activity in vivo. Orally active.

Product Specifications for Dihydroergotoxine mesylate

Storage

Store at RT

CAS Number

8067-24-1

PubChem ID

92044435

InChI Key

HMMYROQEJAZVGJ-CTOOOFERSA-N

SMILES

[H][C@]4([C@@]([H])3C[C@@H]([C@@](N[C@@]5([C@H](C)C)C(N([C@@]([H])([C@@H](C)C)C(N7[C@]([H])6CCC7)=O)[C@@]6(O)O5)=O)=O)CN4C)CC1=CNC2=C1C3=CC=C2.[H][C@]%11([C@@]([H])%10C[C@@H]([C@@](N[C@@]%12([C@H](C)C)C(N([C@@]([H])(CC%15=CC=CC=C%15)C(N%14[C@]([H])%13CCC%14)=O)[C@@]%13(O)O%12)=O)=O)CN%11C)CC8=CNC9=C8C%10=CC=C9.[H][C@]%19([C@@]([H])%18C[C@@H]([C@@](N[C@@]%20([C@H](C)C)C(N([C@@]([H])(CC(C)C)C(N%22[C@]([H])%21CCC%22)=O)[C@@]%21(O)O%20)=O)=O)CN%19C)CC%16=CNC%17=C%16C%18=CC=C%17.[H][C@]%26([C@@]([H])%25C[C@@H]([C@@](N[C@@]%27([C@H](C)C)C(N([C@@]([H])([C@@H](CC)C)C(N%29[C@]([H])%28CCC%29)=O)[C@@]%28(O)O%27)=O)=O)CN%26C)CC%23=CNC%24=C%23C%25=CC=C%24.CS(=O)(O)=O.CS(=O)(O)=O.CS(=O)(O)=O.CS(=O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

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Background References

References are publications that support the biological activity of the product.

Tvredic and Perici Effects of ergot alkaloids on 3H-flunitrazepam binding to mouse brain GABAA receptors. Coll.Antropol. 2003 PMID: 12955907
Tvrdeic and Perici Dihydrogenated ergot compounds bind with high affinity to GABA_A receptor-associated Cl^- ionophore. Eur.J.Pharmacol. 1991 PMID: 1664802
Tvrdeic and Perici Dihydroergotoxine modulation of the GABA_A receptor-associated Cl^- ionophore in mouse brain. Eur.J. Pharmacol. 1992 PMID: 1333969
Abdul Expression of gamma-aminobutyric acid receptor (subtype A) in prostate cancer Acta Oncol. 2008 PMID: 18607852

Product Documents for Dihydroergotoxine mesylate

Certificate of Analysis

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Product Specific Notices for Dihydroergotoxine mesylate

For research use only

Related Research Areas

GABA Receptors

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