Catalog Number: 0505
Biological Activity
A complex of closely related alkaloid salts. Binds with high affinity to the GABAA receptor Cl- channel, producing an allosteric interaction with the benzodiazepine site. Also interacts with central dopaminergic, serotonergic and adrenergic (α1) receptors. Displays antiproliferative activity in vitro (IC50 = 18 - 38 μM in prostate cancer cells) and exhibits cognition-enhancing, anticonvulsant and sedative activity in vivo. Orally active.
Technical Data
  • Solubility:
    Soluble in ethanol
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Expression of gamma-aminobutyric acid receptor (subtype A) in prostate cancer
    Abdul et al.
    Acta Oncol., 2008;47:1546
  2. Dihydrogenated ergot compounds bind with high affinity to GABAA receptor-associated Cl- ionophore.
    Tvrdeic and Perici
    Eur.J.Pharmacol., 1991;202:109
  3. Dihydroergotoxine modulation of the GABAA receptor-associated Cl- ionophore in mouse brain.
    Tvrdeic and Perici
    Eur.J. Pharmacol., 1992;221:139
  4. Effects of ergot alkaloids on 3H-flunitrazepam binding to mouse brain GABAA receptors.
    Tvredic and Perici
    Coll.Antropol., 2003;27:S175

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